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Matthias Weisser's alternative Medizin |
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| Hilfe
1 Psyche
2 Statik
3 Ernährung
4 Gifte
5 Zahnherde
6 Störfelder
7 Parasiten 8 heilende Informationen 9 Selbstheilung 10 Diagnostik 11 Zusammenhänge Literatur |
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"Reparaturenzyme in jeder Zelle beheben durchschnittlich
15000 DNS-Schäden
pro Tag und Zelle mit einem Fehlerkorrektursystem.." Smit
"Giftstoffe zerstören Schlüsselenzyme der Energiegewinnung..
Seeger.." 
"Hauptursache fast aller Krankheiten, vorzeitige Alterung..
Mangel an körpereigenen Enzymen..
erste Symptome: Müdigkeit, Konzentrationsschwäche, Infektanfälligkeit,
Hautprobleme,
allgemeine Unlust, Verdauungsstörungen.." Amelung..
S.8f
"Wer heilt, hat recht"
| Literatur, Patente | |
| -6000: Ägypter: Enzyme zur Herstellung Bier, Wein, Sauerteig, Käse, Joghurt | |
| -1000: Naturvölker in Afrika, Asien, Australien, Amerika benutzen Feigenbaum-Saft, Papaya-Fruchtfleisch, frische Ananas für Wundauflagen offene Geschwüre, Verletzungen -> raschere Heilung | |
| -800: Krebsheilung König Hiskia durch Feigenpflaster.. Bibel. 2. Buch der Könige.. | |
| 502: Aprikosenkerne gg. Krebs in China.. Mangel Vitamin B17.. Lewis: "Medical Botany: Plants Affecting Human Health" S.214 | |
| 1650: Aprikosenöl in England gg. Tumoren, Schwellungen, Geschwüre.. Lewis: "Medical Botany: Plants Affecting Human Health" S.214 in Cole: "Adam in Eden" London 1657 | |
| 1750: Reaumur zeigt Zersetzung Fleisch durch (Substanz im) Magensaft von Greifvögeln.. | |
| 1773: Spallanzani zeigt Zersetzung Fleisch durch (Substanz im) Magensaft bei Bussard.. | |
| 1775: Senebier streicht Magensaft auf offene Beine.. großer Erfolg durch die proteolytischen Enzyme im Magensaft.. Nachahmer nutzen verdünnte Salzsäure -> erfolglos.. | |
| Spallanzani: "Herrn Abt Spallanzanis Versuche über Verdauungsgeschäfte des Menschen und verschiedene Tierarten: nebst einigen Bemerkungen des Herrn Senebier" Leipzig 1775 | |
| Vauquelin: "Experiences qui demontrent la presence de l'acide prussique tout forme dans quelque substances vegetales" Ann Chim 45 206 1800 Cyanid HCN in Aprikosenkernen.. | |
| 1830: Robiquet, Boutron-Charlard stellen reines Amygdalin (Vitamin B17) her.. | |
| Robiquet, Boutron-Charlard: "Extraccon de la Amygdalin" Annales de chimie et de physique 44 325 1830 Extraktion Amygdalin.. | |
| 1833: Anselme Payen findet Enzym Diastase in Malzlösung -> raschere Auftrennung Stärke in Glucose.. | |
| 1836: Theodor Schwann: Entdeckung Pepsin (im Magensaft) -> spaltet Eiweiß.. | |
| 1837: Entdeckung Emulsin (in Bittermandeln) -> vgl. B17 | |
| 1837: alkoholische Gärung durch Hefe unabhängig entdeckt von Charles Cagniard-Latour, Theodor Schwann, Friedrich Kützing.. | |
| 1839: Entdeckung Myrosin (in Senf) | |
| 1848: Trypsin (im Saft der Bauchspeicheldrüse) | |
| 1849: Lipasen -> Fettspaltung | |
| Traube: "Theorie der Fermentwirkungen" Dümmler, Berlin 1858 | |
| 1878: Willy Kühne: Name Enzyme | |
| 1886: Porter: Behandlung Diphtherie mit Trypsin.. | |
| Porter: "Some practical suggestions on the treatment of diphtheria" JAMA 7,17 454-455 23.10.1886 Behandlung Diphtherie mit Enzymen.. Trypsin.. | |
| Buchner: "Alkoholische Gärung ohne Hefezellen" Berichte der Deutschen Chemischen Gesellschaft 30 117-124 1897 Gärung durch Enzyme.. Nobelpreis 1907 | |
| "Fairchild's Hand-Book of the Digestive Ferments" Fairchild Bros & Foster 1898 | |
| Garrod: "A contribution to the study of alkaptonuria" Med Chir Trans 82 367-394 1899 durch Mangel an Enzym.. | |
| Garrod: "About alkaptonuria" Lancet 158,4083 1484-1486 30.11.1901 durch Mangel an Enzym.. | |
| Garrod: "The incidence of alkaptonuria: a study of chemical individuality" Lancet 160,4137 1616-1620 13.12.1902 durch Mangel an Enzym.. | |
| Beard: "Embryological aspects and etiology of carcinoma" Lancet 159,4112 1758-1761 21.6.1902 John Beard.. | |
| 1904: Nobelpreis I.P. Pavlov für Studien zur Verdauung.. Menge/Eigenschaften Magensäfte, Zusammensetzung Speisen.. | |
| Herissey: "Sur la prulaurasine, glucoside cyanhydrique cristallise retire des feuilles de laurier-cerise" C R Acad Sci Paris 141 959-961 1905 Vitamin B17.. Cyanid-Glycosid kristallisiert aus Blättern Lorbeerkirsche.. | |
| Guignard: "Nouvelles observations sur la formation et les variations quantitatives du principe cyanhydrique du Sureau noir" C R Acad Sci Paris 141 1193 1905 Vitamin B17.. the presence of cyanide-yielding compounds in the Elderberry.. schwarzer Hollunder.. | |
| Warburg: "Spaltung des Leuciäthylesters durch Pankreasferment" Berichte der Deutschen Chemischen Gesellschaft 38 187-188 1905 | |
| 1906: Harden, Young: Coferment.. später NAD.. | |
| Beard: "The action of trypsin upon the living cells of Jensen's mouse tumor: a preliminary note upon a research made (with a grant from the Carnegie Fund)" Br Med J 1,2351 140-141 20.1.1906 | |
| Beard: "Trypsin and amylopsin in malignant growths" JAMA 47,6 445 1906 | |
| Wiggin: "Case of multiple fibrosarcoma of the tongue, with remarks on the use of trypsin and amylopsin in the treatment of malignant disease" JAMA 47 2003-2008 1906 | |
| Pinkus, Pinkus: "Die Krebskrankheit und ihre therapeutische Beinflussung durch Fermente" Med Klinik 28-29 1907 | |
| Beard: "The interlude of cancer" Med Rec 71 169-175 1907 | |
| Luther: "The trypsin treatment of cancer" New York Med J 85 341-344 1907 | |
| Campbell: "Trypsin treatment of a case of malignant disease, involving the left tonsil, base of tongue and epiglottis" JAMA 48,3 225-226 19.1.1907 | |
| Goeth: "Pancreatic treatment of cancer, with report of a cure" JAMA 48,12 1030 23.3.1907 | |
| Cutfield: "Trypsin treatment in malignant disease" Br Med J 5 525 1907 | |
| Cleaves: "Physiologic action of the pancreatic enzymes, with special reference to hematology, urology and clinical pathology" Med Rec New York 71 20 1907 | |
| Doran: "Report of a postoperative case of fibroid sarcoma under the enzyme treatment" Med Rec N Y 71 41-44 6.7.1907 | |
| Dupuy: "Favorable effect of trypsin in a case of laryngeal epithelioma: exhibition of a case" New Orleans Med Surg J 59 911-915 1907 | |
| "The trypsin and amylopsin treatment of human cancer [editorial]" Am Med 13 558-560 1907 | |
| Hald: "Comparative researches on the tryptic strength of different trypsin preparations and on their action on the human body" Lancet 170,4394 1371-1375 16.11.1907 stark unterschiedliche Ergebnisse.. | |
| 1907: Nobelpreis E. Buchner für biochemische Forschungen, Entdeckung zellfreie Gärung.. Gärung von Zuckerlösungen mit Hefe, Sand, Kieselgur (Knochenmehl) pulverisiert, hoher Druck.. Enzym Zymase.. | |
| Guignard: "Sur la métamorphose des glucosides cyanhydriques pendant la germination" C R Acad Sci Paris 147 1023-1038 1908 Vitamin B17.. the development of cyanogenetic glucosides during the germination of plants.. | |
| Marsden: "Carcinoma of cervix uteri successfully treated with the pancreatic ferments" General Pract 22-23 1908 | |
| Little: "A case of malignant tumor, with treatment" JAMA 50 1724 1908 | |
| Weinstein: "Dr. Beard's theory in the crucible of test. An experimental study of the trypsin treatment in cancer" N Y State J Med 9 400-402 1908 | |
| Garrod: "Inborn errors of metabolism" Lancet 172 1-7, 73-79, 142-148, 214-220 7.1908 fehlendes Enzym führt zu Erkrankungen wie Alkaptonurie, Albinismus, Cystinurie, Pentosurie.. | |
| Garrod: "The Croonian lectures on inborn errors of metabolism, lecture I" Lancet 172,4427 1-7 4.7.1908 | |
| Garrod: "The Croonian lectures on inborn errors of metabolism, lecture II" Lancet 172,4428 73-79 11.7.1908 | |
| Garrod: "The Croonian lectures on inborn errors of metabolism, lecture III" Lancet 172,4429 142-148 18.7.1908 | |
| Garrod: "The Croonian lectures on inborn errors of metabolism, lecture IV" Lancet 172,4430 214-220 25.7.1908 | |
| Bearn: "Inborn errors of metabolism: Garrod's legacy" Molecular Med 2,3 271-284 5.1996 durch Vererbung fehlende Enzyme können zu Erkrankungen führen wie Alkaptonuria (schwarzer Urin, Alkaptonurie, Albinismus, Cystinurie, Pentosurie.. Veröffentlichungen Garrods.. | |
| Walker, Krieble: "The hydrolysis of amygdalin by acids. Part I" J Chem Soc Trans 95,11 1369-1377 1909 | |
| 1909: Sorensen: pH-Abhängigkeit der Enzymtätigkeit | |
| Freund, Kaminer: "" Wiener Klin Wochenschr 28 120 1910 | |
| Freund, Kaminer: "Über die Beziehungen zwischen Tumorzellen und Blutserum" Biochem Z 26 312 1910 | |
| John Beard: "The Enzyme Treatment of Cancer and its Scientific Basis" Chatto & Windus, London 1911.. 170 Krebspatienten mit Enzymen behandelt.. mehr als 50% der unheilbaren Patienten geheilt.. Tumorwachstum gestoppt, Tumoren aufgelöst.. frischer Saft aus den Bauchspeicheldrüsen junger Lämmer in Tumor gespritzt.. | |
| Abderhalden: "Schutzfermente des tierischen Organismus" Berlin 1912.. | |
| 1912: Entdeckung Dehydrogenasen.. Nachweis der Aktivierung von Wasserstoff.. | |
| Beard: "On the occurrence of dextrorotatory albumins in organic nature" Biolog Zentralblatt 33 150-170 1913 Med Rec 29.3.1913 | |
| Baetzner: "The trypsin treatment of surgical tuberculosis" Practitioner 203-219 1.1913 | |
| Beard: "The nature and treatment of cancer and malaria" Nature 92 60-61 18.9.1913 | |
| Beard: "The pancreatic treatment of tuberculosis and malaria" Nature 92 165-165 9.10.1913 | |
| Lamballe: "The utility of enzymes in malaria" Wood 1913.. Enzyme gg. Malaria.. 13 Seiten.. | |
| Lamballe: "The utility of enzymes in malaria" Med Rec 928-931 22.11.1913 Enzyme Trypsin, Amylopsin erfolgreicher gegen Malaria als Chinin.. keine Rückfälle.. John Beard 1907.. | |
| Willaman: "The estimation of hydrocyanic acid and the probable form in which it occurs in sorghum vulgare" J Biol Chem 29 25-36 1917 Vitamin B17 in Hirse.. Hydrolyse von Amygdalin.. Cyanidgehalt stark abhängig vom Extraktionsverfahren.. 98% durch 24h Emulsin, Wasser bei 45°C.. 26% durch kochende Salzsäure 2% 72h.. 6.7% durch Schwefelsäure 5% 24h.. am meisten durch lange Autolyse bei 45°C.. | |
| Lee: "The systemic causes of dental caries" Vortrag Marquette Universität 12.1923 Karies durch Vitamin-Mangel, Infektionskrankheiten in der Kindheit.. Karies stoppen durch geeignete Ernährung.. B-Vitamine in Milch Keimen, Eiern, Hefe, rohem Gemüse zerstört bei 65.6°C.. Vitamin C zerstört durch Kochen.. endokrine Drüsen erzeugen Fermente die Karies verhindern.. | |
| Josephson: "Die Enzyme des Emulsins I: Über die Amylase-Wirkung einiger Emulsin-Präparate" Berichte der deutschen chemischen Gesellschaft 58,12 2726-2731 30.12.1925 | |
| Warburg: "Über Eisen, den sauerstoff-übertragenden Bestandteil des Atmungsferments" Berichte der Deutschen Chemischen Gesellschaft 58 1001-1011 1925 | |
| Warburg: "Iron, the oxygen-carrier of respiration-ferment" Science 61,1588 575-582 5.6.1925 | |
| Warburg: "Photochemische Versuche über Atmung" Naturwissenschaften 14,50-51 1181 1926 | |
| Karczag, Nemeth: "Über die chemotherapeutische Beeinflussung der experimentellen malignen Geschwülste durch Fermentgifte" Klin Wochenschr 6,23 1091-1092 4.6.1927 Cancer Rev 2 417 1927 effect of enzyme poisons on experimental tumors.. Tiere an Cyankali gewöhnt.. gute Grafiken.. | |
| Karczag: "Die Chemotherapie des Mäusecarcinoms durch Fermentgifte" Klin Wochenschr 6,29 1382-1383 16.7.1927 Cancer Rev 2 467 1927 potassium cyanide inhibited growth of transplanted adenocarcinoma in mice and in some instances caused regression.. Enzymgifte gg. Krebs bei Mäusen.. | |
| Karczag, Csaba: "Treatment of carcinoma with cyanide" Med Klinik 23 1413-1415 1927 Cancer Rev 3 111 1928 Vitamin B17.. | |
| Warburg: "The chemical constitution of respiration ferment" Science 68,1767 437-443 9.11.1928 | |
| Warburg: "Photochemie der Eisencarbonylverbindungen und das absolute Absorptionsspektrum des Atmungsferments" Naturwissenschaften 16,45-47 856-861 1928 | |
| 1929: Nobelpreis A. Harden für Studien über Gärung von Zucker und beteiligte Enzyme.. für Gärung nötig Enzym Zymase, Phosphat, Enzymverbindung (Koenzym).. | |
| 1929: Nobelpreis H. von Euler für Studien über Gärung von Zucker und beteiligte Enzyme.. chemische Natur des Koenzyms.. | |
| Karstrom: "Über die Enzymbildung in Bakterien" Dissertation, Helsingfors 1930 | |
| 1930: ATP als Coenzym analysiert.. | |
| 1930: Freund, Kaminer: Enzymtherapie in Wien wiederentdeckt.. durch Serum gesunder Blutspender (=Normalsubstanz=proteolytische Enzyme) Krebszellen im Reagenzglas aufgelöst.. Serum Krebskranker inaktiv.. Freund-Kaminer-Reaktion.. | |
| Garrod: "The Inborn Factors in Disease" Clarendon Press, Oxford 1931 fehlendes Enzym führt zu Erkrankungen.. | |
| 1931: Nobelpreis Otto Warburg für Entdeckung Natur und Funktion des Atmungsferments.. Enzym das in allen Zellen vorkommt.. Einfluss auf Sauerstoffwechsel.. eng an Hämoglobin gebunden.. macht Oxidationsprozesse möglich.. anderes Enzym der Atmung ist gelbes Enzym.. siehe Nobelpreis H. Theorell 1955.. | |
| Browne: "Progress report on the work done on the hydrocyanic acid content of California grown lima beans" Univ Calif Coll of Agr, Agr Exptl Station, Project No. 521 770 17.6.1932 Vitamin B17.. | |
| Brioux, Jones: "The production of cyanogenetic glycosides by linseed: measurement of HCN production" Ann Agron 8,4 468-480 1932 Vitamin B17 und Leinsamen.. | |
| Warburg, Christian: "Ein zweites sauerstoffübertragendes Ferment und sein Absorptionsspektrum" Naturwissenschaften 20,37 688 1932 | |
| Warburg: "Das sauerstoffübertragende Ferment der
Atmung" Nobelvortrag Stockholm 1933 |
|
| Karrer, Zehender: "Vitamin C as activator of catheptic enzymes" Helv Chim Acta 61 701 1933 Enzyme.. | |
| Purr: "The influence of vitamin C on intracellular enzyme action" Biochem J 27 1703 1933 Enzyme.. | |
| 1933: gelbes Ferment (Flavienzym) besteht aus Vitamin B2 und spezifischem Protein.. | |
| Maxwell, Bischoff, Ullmann: "Studies in cancer chemotherapy XI. The effect of CO, HCN, and pituitrin upon tumor growth" J Pharmacol Exp Ther 49,3 270-282 11.1933 Untersuchung kumulative Effekte von HCN in Mäusen: nach 21 Tagen HCNExposition stiegen rote Blutkörperchen, Hämoglobin Mäuse 12 -> 15%, Ratten 20 -> 25%.. Jensen-Sarkom.. | |
| Warburg, Haas: "Über eine Absorptionsbande im Gelb in Bäckerhefe" Naturwissenschaften 22,13 207 1934 | |
| Warburg: "Sauerstoffübertragende Fermente" Naturwissenschaften 22,26 441-446 1934 | |
| Warburg, Negelein: "Cytochrom und sauerstoffübertragendes Ferment" Naturwissenschaften 22,13 206-207 1934 | |
| Morse: "Treatment of cancer with pancreatic extract" Weekly Bull St. Louis Med Soc 28 599-603 1934 | |
| Lineweaver, Burk: "The determination of enzyme dissociation constants" J Am Chem Soc 56,3 658-666 3.1934 | |
| Liebesny: "Kurz- und Ultrakurzwellen. Biologie und Therapie" Urban & Schwarzenberg 1935 Beeinflussung Pflanzen, Mikroorganismen, Fermente, Enzyme, Wachstum, Virulenz.. Kurzwellen bei entzündlichen Erkrankungen, Osteomyelitis, Sepsis, Tuberkulose, Krebs, Lungenkrankheiten, Lähmungen, Schizophrenie, Nervenerkrankungen, Gefäßerkrankungen, Angina pectoris, Migräne.. | |
| Purr: "The activation phenomena of papain and cathepsin" Biochem J 29 13 1935 Enzyme.. | |
| Schiff: "Über den Abbau gruppenspezifischer Substanzen durch Bakterien" Klin Wochenschr 14 750-751 1935 | |
| Perry: "The effect of prolonged cyanide treatment on body and tumor growth in rats" Am J Cancer 25 592 11.1935 Vitamin B17.. Verweis auf Karczag, Maxwell, Bischoff.. Adenokarzinom Mäuse, Jensen-Sarkom Ratten.. | |
| 1935: Szent-Györgyi: enzymatische Oxidation Succinat (Bernsteinsäure) zu Oxalacetat.. | |
| 1935: Warburg: wasserstoffübertragendes Coferment.. heute NADP/NAD.. | |
| Oelgoetz, Oelgoetz, Wittekind: "The treatment of food allergy and indigestion of pancreatic origin with pancreatic enzymes" Am J Dig Dis 2,7 422-426 7.1935 pankreatische Enzyme gg. Allergie.. einfacher Test für Nahrungsmittelallergien.. | |
| Oelgoetz, Oelgoetz, Wittekind: "Further studies in food allergy" Med Rec 143 20 1936 pankreatische Enzyme gg. Allergie.. | |
| Oelgoetz, Oelgoetz, Wittekind: "The origin, fate and significance of the serum enzymes" Am J Digest Dis 3,3 159-161 3.1936 pankreatische Enzyme.. | |
| Fischer-Wasels: "Versuche zum Nachweis des spezifischen Agens (Virusenzyms) bei bösartigen Geschwülsten" Z Krebsforschung (Berlin) 44 157-159 1936 | |
| Kohman, Eddy, White, Sanborn: "Comparative experiments with canned, home cooked and raw food diets" J Nutr 14,1 9-19 1.7.1937 Dosennahrung macht dick im Vergleich zu Rohkost.. Kochen zerstört Enzyme.. | |
| 1937: enzymatische Oxidation Citrat (Zitronensäure) zu Succinat.. | |
| 1937: Krebs: kompletter oxidativer Endabbau von Proteinen, Fetten, Kohlehydraten zu CO2 und H2O.. Synthese von ATP mittels reduzierter Coenzyme in der Atmungskette.. | |
| 1937: Nobelpreis A. Szent-Györgyi für Entdeckungen Prozesse biologische Verbrennung.. Vitamin C hilft Wasserstoff oxidieren.. Rauchsäure (Fumarsäure) wasserstoffleitende Substanz.. | |
| Szent-Györgyi: "Oxidation, energy transfer, and vitamins" Nobelpreisrede 11.12.1937 Energie durch Oxidationsstoffwechsel aus H2 und O2.. enzymatische Aktivierung Wasserstoff.. Warburgs Atmungsenzym Cytochromoxidase aktiviert Sauerstoff.. Farbstoffe Cytochrome und Cytoflav (gelbes Enzym) erforderlich = Lactoflavin (Vitamin B).. Nebennieren enthalten viel Hexuronsäure=Vitamin C.. bei Fehlen braune Flecken.. Addison-Krankheit.. geschädigte Oxidation.. Kristalle aus Zitronensaft mit Antiskorbutwirkung -> Vitamin C.. viel mehr Vitamin C aus ungarischen Paprika gewonnen.. in 2 Jahren billiges synthetisches Produkt.. Kollege mit Blutungen durch Paprika geheilt.. pures Vitamin C reicht nicht, Flavone nötig.. Hesperidin, Eriodictyolglycosid.. beeinflussen Kapillaren, normalisieren.. Vitamin P.. | |
| Northrop: "Crystalline enzymes" Columbia University Press, New York 1939 | |
| Buchs: "Über das Kathepsin des Magensaftes" Dissertation Basel 1940 | |
| Jordan: "Über die Spezifität von Antikörpern, Fermenten, Viren, Genen" Die Naturwissenschaften (Berlin) 29 89-100 1941 | |
| US-Patent 2464240: Herstellung therapeutisches Material gg. Asthma etc. Krebs, Krebs 20.11.1943 -> 15.3.1949 Vitamin aus Aprikosenkernen zur Entgiftung.. gg. Schmerzen.. Vitamin B17.. | |
| 1943: Butenandt: Wirkungsweise Erbfaktoren über Enzyme.. | |
| "Chronic fluorine intoxication" JAMA 123,3 150-151 18.9.1943 Fluorid giftig.. Fluoride als Protoplasmagifte.. verändern Permeabilität der Zellmembran.. blockieren bestimmte Enzymsysteme.. Quellen für Fluorid sind Trinkwasser mit >1ppm Fluor.. Fluorid in Insektizidsprays für Obst/Gemüse.. Phosphatdünger.. | |
| Bogomoletz: "Antireticular cytotoxic serum" Br Med J 2,4310 203 14.8.1943 Abwehr vom Bindegewebe abhängig.. Bogomoletz-Serum 2500 Fälle: wirksam bei schlecht heilenden Knochenbrüchen, schlecht heilenden infizierten Verletzungen, Infektionskrankheiten, Meningitis, Neuritis, Psychosen, Schizophrenie, Blutvergiftung, Sepsis, Rheuma, Lungenentzündung, Tonsilitis, Tumoren, Geschwüre Magen, Darm, Ekzeme.. | |
| Abderhalden: "Die Abbaufermente" Verlag Th. Steinkopf, Berlin 1944 | |
| Davison: "Synopsis of Materia Medica, Toxicology and Pharmacology. For students and practitioners of medicine" 3. Auflage C.V. Mosby, St. Louis 1944 Amygdalin-Injektion erzeugt keine schädliche Wirkung.. | |
| Franklin, Reid: "Observations on the cyanogenetic properties of linseed nuts. Part 1 feeding trials with sheep" Austral Vet J 20,6 332-337 12.1944 Schafe können 8-10mg HCN/kg pro Tag als Leinsamen mit Linamarin aufnehmen ohne zu sterben.. bei 70kg -> 700mg HCN.. tödliche Dosis nicht normal erreichbar, nur durch Zwangsfütterung.. Vitamin B17.. | |
| Bach: "A.C.B. Serum of Prof. Bogomoletz in the treatment of rheumatism" Ann Rheum Dis 4,3 62-64 3.1945 Besserung Rheuma, rheumatoide Arthritis in 14 von 48 Fällen.. Stimulation Bindegewebe, Aktivierung Mesenchym.. Serum durch Immunisierung Pferde mit Zellen aus Milz, Knochenmark von plötzlich verstorbenen Menschen.. | |
| Mendel, Rudney, Bowman: "Rhodanese and the Pasteur effect" Cancer Res 6 495 1946 | |
| Fischer: "Mechanism of the proteolytic activity of malignant tissue cells" Nature 157 442 6.4.1946 | |
| Howell: "The Status of Food Enzymes in Digestion and Metabolism" National Enzyme Co, Chicago 1946.. | |
| Warburg: "Schwermetalle als Wirkungsgruppen von Fermenten" Berlin 1946 | |
| 1946: Nobelpreis James B. Sumner für Entdeckung Kristallisation Enzyme.. Herstellung Enzym Urease in reinkristallinem Zustand.. löst Harnstoffzerfall aus.. Pulverisierung Pflanze Canavalia ensiformis in flüssigem Aceton.. Kristalle nach Abkühlen der Lösung.. Rekristallisation.. | |
| 1946: Nobelpreis John H. Northrop für Reinherstellung der Enzyme.. Reinherstellung Pepsin aus Magensäure, Tripsin aus Bauchspeicheldrüse.. sind Proteine.. | |
| 1946: Nobelpreis W.M. Stanley für virenartige Proteine.. aus Tabakblättern mit Befall Tabakmosaikvirus kristalline Substanz herausgelöst als Krankheitserreger.. | |
| Warburg: "Ideen zur Fermentchemie der Tumoren" Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin 1947 | |
| Astrup, Permin: "Fibrinolysis in the animal organism" Nature 159 681 1947 | |
| Renshaw: "Intestinal extract in rheumatic diseases" Ann Rheum Dis 6 15-35 1947 Rheuma wg. fehlerhafter Eiweiß-Verdauung.. Mangel an Enzymen -> Enzyme an 700 Privatpatienten -> Erfolge bei rheumatoider Arthritis, Osteoarthritis, Fibrositis, Ankylosing spondylitis.. | |
| Krebs, Krebs, Gurchot: "Skeletal changes associated with the use of crystalline chymotrypsin in an apparently radio-resistant growth" Med Rec 160 479 8.1947 | |
| Fishman, Anlyan: "The presence of high beta-glucuronidase activity in cancer tissue" J Biol Chem 169,2 449-450 7.1947 Vitamin B17.. viel beta-glucuronidase in Krebsgewebe.. | |
| Fishman: "B-glucuronidase activity of the blood and tissue of obstetrical and surgical patients" Science 105,2738 646-647 20.6.1947 Vitamin B17.. viel beta-glucuronidase in Krebsgewebe.. | |
| Fishman, Anlyan: "A comparison of the beta-glucuronidase activity of normal, tumor, and lymph node tissues of surgical patients" Science 106,2742 66-67 18.7.1947 Vitamin B17.. viel beta-glucuronidase in Krebsgewebe.. | |
| Fishman, Anlyan: "beta-glucuronidase activity in human tissues; some correlations with processes of malignant growth and with the physiology of reproduction" Cancer Res 7,12 808-817 12.1947 Vitamin B17.. viel beta-glucuronidase in Krebsgewebe.. | |
| Abderhalden, Mouriquand: "Vitamine und Vitamintherapie" Huber, Bern 1948 Vitamine lebenswichtig, sie wirken in geringen Mengen und kommen weder als Energielieferanten noch als Bausteine für den Organismus und seine Zellen in Betracht.. | |
| Warburg: "Wasserstoffübertragende Fermente" Berlin 1948 | |
| Levy, Kerr, Campbell: "ß-Glucuronidase and cell proliferation" Biochem J 42,3 462-468 1948 Vitamin B17.. beta-glucuronidase in Krebsgewebe.. Mentholgabe löst Enzym aus.. Grafiken.. | |
| Clark, Cliffton, Newton: "Antiproteolytic activity of human serum with particular reference to its changes in the presence and considerations of its use for detection of malignant neoplasia" Proc Soc Exp Biol Med 69,2 276-279 11.1948 | |
| West, Hilliard: "Proteolytic enzyme inhibitors of human serum in health and disease" Proc Soc Exp Biol Med 7 2 6.1949 Enzym Chymotrypsin proportional zu Tumor-Wachstum oder -Rückbildung.. Test zeigt Therapieerfolg an.. | |
| West, Hilliard: "Proteolytic enzyme inhibitors of the blood in relation to neoplastic diseases" Ann West Med Surg 3 227 1949 | |
| Cliffton: "The antiproteolytic reaction, iodoacetate index and least coagulable protein reactions in relation to malignant neoplasia; correlation of tests" J Natl Cancer Inst 10,3 719-723 12.1949 | |
| Stack, Morgan: "The preparation and properties of enzymes from Clostridium welchii (type B) filtrates which destroy blood-group substances" Br J Exp Pathol 30,5 470-483 10.1949 | |
| Waldvogel, Marvin, Wells: "Determination of serum antitrypsin in the study of malignant neoplasia" Proc Soc Exp Biol Med 72,1 100-102 10.1949 | |
| Dillard, Chanutin: "The protease and antiprotease of plasmas of patients with cancer and other diseases" Cancer Res 9,11 665-668 11.1949 | |
| Dillard: "The trypsin inhibitor of the urine in health and disease" J Lab Clin Med 36,2 266-271 8.1950 | |
| US-Patent 2503313: Erzeugung getrocknete, entfettete Enzyme. Levin 14.4.1947 -> 11.4.1950 wirksame Enzyme gewinnen aus Drüsen von Vieh, Schafen, Widschweinen, Pferden.. erst Fett entfernen durch Lösemittel, dann Vakuumdestillation -> meiste Enzyme bleiben erhalten.. Fa. Viobin liefert jahrelang Pankreatin in verschiedenen Stärken.. | |
| West: "Enzyme inhibitors of the serum in relation to neoplastic disease activity" Cancer Res 10,4 248 4.1950 | |
| Luh, Pinochet: "Spectrophotometric determination of hydrogen cyanide in canned apricots, cherries and prunes" Food Res 24 423-427 1950 | |
| Cliffton: "An evaluation of the antiproteolytic reaction of serum as a test for malignant neoplasia" J Natl Cancer Inst 11 33 1950 | |
| Astrup: "Fibrokinase" Acta Physiol Scand 24 267 1951 | |
| 1951: Lynen, Lipmann: Aufklärung Coenzym A.. | |
| Iseki, Okada: "On a specific enzyme which decomposes group A substance" Proc Japan Acad 27 455-458 1951 | |
| Iseki, Tsunoda: "On a bacterial enzyme which specifically decomposes 0 substance" Proc Japan Acad 28,7 370-373 1952 | |
| Cliffton: "Variations in the proteolytic and the antiproteolytic reactions of serum: effect of disease, trauma, X-ray, anaphylactic shock, ACTH and cortisone" J Lab Gin Med 39 105 1952 | |
| Kihn: "Erfahrungen mit dem antireticulären cytotoxischen Serum nach Bogomoletz" Med Klinik 47 1122-1127 1952 | |
| Jacobsson: "Electrophoretic demonstration of two trypsin inhibitors in human blood serum" Scand J Clin Lab Invest 5,1 97-98 1953 | |
| Kihn: "Klinische Erfahrungen mit dem antiretikulären Serum nach Bogomoletz" Med Klinik 15 1953 | |
| "Treatment of cancer with laetriles; a report by the Cancer Commission
of the California Medical Association" Calif Med 78,4 320-326 4.1953
California Report von Ian MacDonald, Henry Garland: gefälschter
Bericht..
vgl. Griffin: "World without Cancer" S.32 |
|
| US-Patent 2710876: N-substituted glycine esters of gluconic acid. Krebs, Krebs 9.12.1953 -> 14.6.1955 Amygdalin aus Aprikosenkernen.. Vitamin B17.. | |
| Atkins: "The serological inactivation of the human blood group substances by an enzyme preparation obtained from Trichomonas foetus" Biochem J 54,33 1953 | |
| 1953: Nobelpreis Hans Krebs für Entdeckung Zitronensäurezyklus.. Enzyme zur Umwandlung nötig.. | |
| 1953: Nobelpreis Fritz A. Lipmann für Entdeckung Koenzym A und Bedeutung im Stoffwechsel.. | |
| Gaschler: "Die parenterale Fermenttherapie maligner Tumoren und chronischer Entzündungszustände" Pharmalabor S. M. Gaschler 1954 Auflösung Tumoren mit Trypsin an Berliner Charité 1941.. Carzodelan forte pro inject.. | |
| Watkins, Morgan: "Inactivation of the H receptors on human erythrocytes by an enzyme obtained from Trichomonas foetus" Br J Exp Pathol 35,2 181-190 4.1954 Trypsin löscht Information.. Virus-Rezeptoren zerstört.. 9 Blutgruppensysteme, 30 Antigene.. | |
| Cliffton, Grossi: "Fibrinolytic activity of human tumors as measured by the fibrin-plate method" Cancer 8,6 1146-1154 1955 2 Enzymsysteme in Tieren.. eines braucht Streptokinase, das andere Fibrokinase.. Heparin hemmt Trypsin, Plasmin.. | |
| 1955: Nobelpreis A.H.T. Theorell für Entdeckung Natur und Reaktionsweise der oxidierenden Enzyme.. gelbes Enzym der Atmung.. enthält Riboflavin (Vitamin B2) und Phosphorsäure.. | |
| Festenstein, Heaton, Lowe, Morton: "A constituent of the unsaponifiable portion of animal tissue lipids" Biochem J 59 558-566 1955 Entdeckung Q10.. | |
| Cliffton, Grossi: "Effect of human plasmin on the toxic effects and growth of blood borne metastatis of the Brown-Pearce carcinoma and the V2 carcinoma of rabbit" Cancer 9,6 1147-1152 1956 | |
| Giordano, Violante, Lerenzetti, Sapio: "Rhodanese activity of the neoplastic and hemopoietic tissues of rats with myeloma in leukemic phase" Biochemie Appl 3 284 1956 Cyanid-Entgiftung.. | |
| Burns, Moltz, Peyser: "Missing step in guinea pigs required for the biosynthesis of L-ascorbic acid" Science 124,3232 1148-1149 7.12.1956 Vitamin C-Synthese.. | |
| Astrup: "Fibrinolysis in the organism" Blood 11 781-806 1956 | |
| Weinhouse: "On respiratory impairment in cancer cells" Science 124 267-269 1956 | |
| Warburg: "On respiratory impairment in cancer cells" Science 124 269-270 1956 | |
| Burk, Schade: "On respiratory impairment in cancer cells" Science 124 270-272 1956 | |
| Howe, MacLennan, Mandl, Kabat: "Enzymes of Clostridium tertium. Effects on blood group and virus receptor substances" J Bacteriol 74,3 365-376 9.1957 Enzymwirkung auf Blutgruppen und Viren.. | |
| Grollman, Lehninger: "Enzymic synthesis of L-ascorbic acid in different animal species" Arch Biochem Biophys 69 458-467 7.1957 enzymische Vitamin C-Erzeugung bei Tieren.. | |
| Beard: "Enzyme-hormone antagonism. I. Chymotrypsin and amylases vs chorionic and anterior pituitary lutenizing hormones" Enzymologia 18,5 293-308 31.7.1957 Hirnanhangdrüse Hypophyse.. | |
| Beard: "Enzyme-hormone antagonisms. II. A simple method for determining the lutenizing hormones of the anterior pituitary and of chorionic gonadotrophin" Enzymologia 18,5 309-319 31.7.1957 Hirnanhangdrüse Hypophyse.. | |
| Beard: "Enzyme-hormone antagonism. III. The excretion of the lutenizing hormone of chorionic gonadotrophin in urines from normal, pregnant and malignant individuals" Enzymologia 18,5 320-326 31.7.1957 | |
| Jones, Fleming, Bailey: "Cyanide as a growth-inhibiting substance in extracts of peach leaves, bark, and flower buds" Proc Amer Soc Hort Sci 69 152-157 1957 Vitamin B17.. | |
| Crane: "Electron transport and cytochromes of sub-cellular particles from cauliflower buds. Plant Physiol 32 619-625 1957 Q10.. | |
| Crane, Hatefi, Lester, Widmer: "Isolation of a quinone from beef heart mitochondria" Biochim Biophys Acta 25 220-221 1957 Q10.. | |
| Astrup, Albrechtsen: "Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues" Scand J Clin Lab Invest 9,3 233-243 1957 | |
| Moser: "Intramuscular injection of trypsin: its value as a thrombolytic and anti-inflammatory agent" N Engl J Med 256,6 258-263 7.2.1957 | |
| Abderhalden: "Klinische Enzymologie. Die Fermente in d. Pathogenese, Diagnostik u. Therapie" Thieme, Stuttgart 1958.. | |
| Knox: "Sir Archibald Garrod's Inborn errors of metabolism. I. Cystinuria" Am J Hum Genet 10,1 3-32 3.1958 | |
| Knox: "Sir Archibald Garrod's Inborn errors of metabolism. II. Alkaptonuria" Am J Hum Genet 10,2 95-124 6.1958 | |
| Knox: "Sir Archibald Garrod's Inborn errors of metabolism. III. Albinism" Am J Hum Genet 10,3 249-267 9.1958 | |
| Knox: "Sir Archibald Garrod's Inborn errors of metabolism. IV. Pentosuria" Am J Hum Genet 10,4 385-397 12.1958 | |
| Astrup: "Die Bedeutung der Fibrinolyse" Med Grundlagenforschung Bd. 2 Thieme, Stuttgart 1959 | |
| Navarro: "Five years experience with laetrile therapy in advanced cancer" Acta Unio Int Contra Cancrum 15,suppl 1 209-221 1959 Vitamin B17.. stimmt das Datum? | |
| Nardi: "Serum 'trypsin' (or arginine exopeptidase) screening test for cancer of the pancreas" Gastroenterology 38 50-51 1.1960 | |
| Brown, Wood, Smith: "Sodium cyanide as a cancer chemotherapeutic agent" Am J Obstet Gynecol 80,5 907-918 11.1960 Na-Cyanid als Enzymhemmer.. regionale Anwendung ohne chron. Giftigkeit.. Verteilung zu sehen.. verlängertes Überleben.. Sarcoma 180 -> 0.8mg/kg Cyanid -> 70% Lebensverlängerung bei Mäusen.. auch Ehrlich Ascites-Zelltumoren.. | |
| Jones, Enzie: "Identification of a cyanogenetic growth-inhibiting substance in extracts of peach flower buds" Science 134,3474 284 28.7.1961 Vitamin B17.. | |
| Broome: "Evidence that the L-asparaginase activity of guinea pig serum is responsible for its antilymphoma effects" Nature 191 1114-1115 9.9.1961 gg. Lymphome.. | |
| Grossi, Agostino, Melamed, Cliffton: "The effect of human fibrinolysin on survival of carcinosarcoma 256 walker cells in the blood" Cancer 14,5 957-962 1961 | |
| Navarro: "Laetrile therapy in cancer" Philippine J Cancer 4 204-209 1962 | |
| Cliffton, Agostino: "Factors affecting the development of metastatic cancer. Effect of alterations in clotting mechanism" Cancer 15,2 276-283 1962 Verklumpung und Krebs.. mehr Metastasen nach Entfernung Primärtumor.. | |
| Seligman: "Bromelain: an anti-inflammatory agent" Angiology 13 508-510 1962 antientzündlich.. | |
| Morrone: "Chemotherapy of inoperable cancer: preliminary report of 10 cases treated with laetrile" Exp Med Surg 20 299-308 1962 Vitamin B17.. Tumorrückbildung, starke Schmerzlinderung, mehr Appetit.. | |
| Blum, Woodring: "Secretion of benzaldehyde and hydrogen cyanide by the millipede Pachydesmus crassicutis (wood)" Science 138,3539 512-513 26.10.1962 Tausendfüßler erzeugt Mischung aus Benzaldehyd und Cyanid gg. Angreifer.. | |
| Jones, Parsons, Rothschild: "Release of hydrocyanic acid from crushed tissues in all stages of the life-cycle of species of the Zygaeninae (Lepidoptera)" Nature 193,4810 52-53 6.1.1962 50 zerstörte Motteneier wiegen 2.6-4mg und setzen bis 150µg Cyanid frei.. entspricht 5% des Gewichts der Eier.. | |
| 1963: Max Wolf: Vortrag im Schwabinger Krankenhaus, München über WoBe.. | |
| Pfeiffer: "Therapeutische Möglichkeiten mit proteolytischen Enzymen" Ärztliche Praxis 45 2471 1963 lange Abhandlung über WoBe.. Verhinderung Rezidive, Metastasen.. Eliminierung Schmerzen.. Besserung Allgemeinbefinden.. gute Erfolge bei Pleura-, Peritonealeffusionen.. introtumorale Injektionen.. | |
| Broome: "Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance" J Exp Med 118 99-120 7.1963 Asparaginase unterdrückt Lymphome.. Grafiken.. | |
| 1963: Cecile Hoffman: Gründung International Association of Cancer Victims and Friends IACVF zur Information der Öffentlichkeit.. jährliche Tagungen in LA.. | |
| Sayre, Kaymakcalan: "Cyandide poisoning from apricot seeds among children in central Turkey" N Engl J Med 270 1113-1115 21.5.1964 versehentliche Einnahme wilder Aprikosenkerne mit 2000mg HCN pro kg, 35g Nitriloside.. die Kerne werden als Delikatesse gesehen.. Eltern glauben sie seien gut für die Gesundheit und halten die Kinder nicht davon ab diese zu essen.. Tabelle der Vergiftungen von 1957-1962.. | |
| Krebs, Beard, Bouziane, Navarro, Morrone, Guidetti: "The Laetriles - Nitrilosides - in the Prevention and Control of Cancer" Intl Assoc of Cancer Victims and Friends, McNaughton Foundation 1964.. Erfolg mit Vitamin B17.. | |
| Krebs: "The nitrilosides in plants and animals. Nutritional and therapeutic implications" 1964 sehr guter Artikel über Vitamin B17, Cyanid.. gute Quellenangaben.. | |
| King: "Prevention of virus-induced mammary tumours by an orally active pancreas factor" Exp Med Surg 23 345-347 1965 Tumorverhinderung durch Pankreatin bei C3H-Mäusen mit Bittner's Milchfaktor.. 100% Tumoren in Kontrollgruppe.. | |
| Stone: "Studies of a mammalian enzyme system for producing evolutionary evidence on man" Am J Phys Anthropol 23 83-86 3.1965 Enzymsystem zur Erzeugung Vitamin C bei Säugetieren.. | |
| 1965: Raummodell für Enzym Lysozym.. | |
| Navarro: "A screening test for malignancy" J Philippine Med Assoc 1965 | |
| Navarro: "Immunological test for cancer" Santo Tomas J Med 21,6 11.-12.1966 | |
| 1966: FDA stoppt Dr. Shively nach 1305 Injektionen pankreatische Enzyme gg. Krebs.. William Donald Kelley macht weiter mit oraler Anwendung.. | |
| Boeryd, Rudenstam: "Effect of heparin, plasminogen inhibitor (EACA) and trauma on tumour metastases" Acta Pathol Microbiol Scand 69,1 28-34 7.1967 Thrombenbildung -> mehr Krebsgefahr.. mehr Metastasen nach Trauma.. | |
| Astrup: "Biologie des Plasmins" Thrombos Diathes haemorrh Suppl 22 5 1967 | |
| Burk, Woods: "Newer aspects of glucose fermentation in cancer growth and control" Arch Geschwulstforsch 28 305-319 1967 | |
| Haberditzl: "Enzyme activity in high magnetic fields" Nature 213 72-73 1967 | |
| Chappel: "Toxicity studies on Amygdalin" McNaughton Foundation, Montreal, Canada 1967 Vitamin B17.. | |
| Kochibe, Iseki: "Immunochemical studies on bacterial blood group substances. V." Japan J Microbiol 12,4 403-411 1968 | |
| Stojanov: "Proteolytische Enzyme und Krebs" Krebsarzt 23 373-380 1968 | |
| Adamson, Fabro: "Antitumor activity and other biologic properties of L-asparaginase (NSC-109229) - a review" Cancer Chemother Rep 52,6 617-626 10.1968 | |
| Ries, Ludwig, Appel: "Antikoagulantien bei der Strahlenbehandlung weiblicher Genitalkarzinome" Med Welt 19 2042-2047 1968 Enzyme reduzieren Rezidive.. | |
| 1965: Synthese Ribonuklease A.. | |
| von Ardenne, Chaplain, Reitnauer: "Selektive Krebszellenschädigung durch eine Attackenkombination mit Übersäuerung, Hyperthermie, Vitamin A, Dimethylsulfoxoid und weiteren die Freisetzung lysosomaler Enzyme fördernden Agenzien" Archiv für Geschwulstforschung 33,4 331-344 1969 selective injury to cancer cells by a combined attack with acidification, heat, vitamin A, dimethyl sulfoxide and other agents facilitating the release of lysosomal enzymes.. | |
| Shively: "Multiple Proteolytic Enzyme Therapy of Cancer" Johnson-Watson, Dayton 1969 | |
| Cliffton: "Fibrinolysis treatment of cancer" Intl Symp Therapeutische und exp Fibrinolyse 1969 | |
| Agostino, Cliffton: "Fibrinogen levels and pulmonary metastases in rats. Effect of tissue damage" Arch Pathol 87,2 141-145 2.1969 Fibrinogen hoch -> viele Metastasen.. | |
| Folkers, Littarru, Ho, Runge, Havanonda, Cooley: "Evidence for a deficiency of coenzyme Q10 in human heart disease" Int Z Vitaminforsch 40,3 380-390 1970 | |
| Navarro: "The Philippine experience in the early detection and chemotherapy of cancer" St Tomas J Med 25,3 125-133 1970 | |
| Krebs: "The nitrilosides (vitamin B-17) - their nature, occurence and metabolic significance (antineoplastic vitamin B-17)" J Appl Nutr 22,3-4 1970 Vitamin B17.. | |
| Krebs: "" Kongress Intl Med Soc for Blood and Tumor Disease, Baden-Baden 7.11.1970 Vortrag zu Nitrilosiden.. vgl. J Appl Nutr 22,3-4 1970 Vitamin B17.. | |
| Burk, Nieper: "Problems of early cancer diagnosis and therapy" Aggressologie 11,1 1-7 1970 Vitamin B17.. Prävention, Therapie.. | |
| Burk: "Effects of amygdalin, prinasin, mandelonitrile, and HCN-benzaldehyde on the Pasteur effect, metabolic death, and trypan blue staining of Ehrlich ascites carcinoma cells" Progress in Antimicrobial and Anticancer Chemotherapy. Proc 7th Intl Congress of Chemotherapy 1971 synergistischer Effekt Benzaldehyd + Cyanid bei Stoffwechselschädigung Maustumoren im Warburg-Apparat.. | |
| Burk, McNaughton, von Ardenne: "Hyperthemy of cancer cells with amygdalin-lucosidase, and synergistic action of derived cyanide and benzaldehyde" PanMinerva Med 13,12 520 12.1971 synergistischer Effekt Benzaldehyd + Cyanid bei Stoffwechselschädigung Maustumoren im Warburg-Apparat.. | |
| Gurchot: "Suggested mechanisms of action of vitamin B17" Wirkmechanismus, Synergie Benzaldehyd, Cyanid.. Dean Burk 1971.. | |
| "The Laetrile Story" Cancer News J 20 1971 Erfolge von Dr. Bouziane mit Laetrile.. | |
| Littaru, Ho, Folkers: "Deficiency of coenzyme Q10 in human heart disease. I." Int J Vitam Nutr Res 42,2 291-305 1972 | |
| Littarru, Ho, Folkers: "Deficiency of coenzyme Q10 in human heart disease. Part I and II" Int J Vit Nutr Res 42,2 291-305 und 42,3 413 1972 | |
| Romero, Pairent, Appert, Howard: "The twenty-four excretion of trypsin and trypsinogen in the urine" Ann Surg 176,2 154-158 8.1972 | |
| Keim, Al-Yousef, Wachter: "Methode zur Milderung der Lymphstauung am Arm nach Behandlung des Mammakarzinoms" Röntgenberichte 1 45 1972 Enzyme gg. Stau.. | |
| Rokitansky: "Zur Enzymtherapie maligner Tumoren" Ärztliche Praxis 24 2307 1972 | |
| Heinicke, van der Wal, Yokoyama: "Effect of bromelain (Ananase) on human platelet aggregation" Experientia 28,7 844-845 15.7.1972 | |
| Culliton: "Sloan-Kettering: The trials of an apricot pit - 1973" Science 182,4116 1000-1003 7.12.1973 Vitamin B17.. | |
| Brown: "The effect of lung irradiation on the incidence of pulmonary metastases in mice" Br J Radiol 46,548 613-618 8.1973 Strahlung -> Fibrinogen hoch -> viele Metastasen.. | |
| Luosto, Koikkalainen, Sipponen: "Spontaneous regression of a bronchial carcinoid tumour following pregnancy" Ann Chir Gynaecol Fenn 63,4 342-345 1974 Spontanrückbildung Tumor nach Schwangerschaft.. Embryo erzeugt pankreatische Enzyme die Tumor der Mutter abstoßen.. | |
| Percy: "You Live to be 100 in Hunza" Parade 17.2.1974 Senator Charles Percy.. | |
| Bartsch: "Zur Therapie des Zosters mit proteolytischen Enzymen" Der informierte Arzt 2,10 2-7 1974 Herpes Zoster.. | |
| Krebs, Bouziane: "Nitrilosides (laetriles): Their rationale and clinical utilization in human cancer" 1974 Vitamin B17.. | |
| Ross: "Editorial: Laetriles - not a vitamin and not a treatment" West J Med 122,4 326-327 4.1975 Desinformation.. | |
| Krebs: "Anatomy of a cover-up: successful Sloan-Kettering amygdalin (laetrile) animal studies" Committee for Freedom of Choice in Cancer Therapy, Los Altos, California 1975 zurückgehaltene Daten von Dr. Sugiura.. Laetrile reduziert Metastasen bei Brustkrebs.. | |
| Dunzendorfer: "Die Isoenzyme des Plasmins" Clinica Chimica Acta 64,1 87-90 1.10.1975 | |
| Ahmed, Claderwood, Fröhlich, Smith: "Evidence for collective magnetic effects in an enzyme. Likelihood of room temperature superconductive regions" Phys Lett 53A 129 1975 | |
| Fröhlich: "The extraordinary dielectric properties of biological materials and the action of enzymes" Proc Natl Acad Sci USA 72,11 4211-4215 11.1975 viele Biomoleküle schwingfähig bei 10e11Hz.. | |
| Moncada, Gryglewski, Bunting, Vane: "An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation" Nature 263 663-665 21.10.1976 PGX verhindert Blutverklumpung.. | |
| Mitchell: "Possible molecular mechanisms of the protonmotive function of cytochrome systems" J Theoret Biol 62 327-367 1976 | |
| Nieper: "Bromelain in der Kontrolle malignen Wachstums" Krebsgeschehen 8 9-15 1976 | |
| Eyerly: "Laetrile: Focus on the facts" CA Cancer J Clin 26,1 50-54 1976 Vitamin B17, Desinformation, Unterdrückung.. | |
| Hansen: "Bioenergetics in clinical medicine. Gingival leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease" Res Commun Chem Pathol Pharmacol 14,4 729-738 1976 Parodontose.. | |
| Yamagami, Shibata, Folkers: "Bioenergetics in clinical medicine: VIII. Administration of coenzyme Q10 to patients with essential hypertension" Res Commun Chem Pathol Pharmacol 14,4 721-727 1976 | |
| Ernster: "Facts and ideas about the function of coenzyme Q10 in the mitochondria" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 15-18 1977 | |
| Cortes, Mohinder, Patel, Mundia, Folkers: "Study of administration of coenzyme Q10 to adriamycin treated cancer patients" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 267-273 1977 | |
| Shaya, Smith: "The effects of magnetic and radiofrequency fields on the activity of lysozyme" Coll Phenom 2 215-218 1977 | |
| Peterson: "Fibrinolysis and antifibrinolytic drugs in the growth and spread of tumours" Cancer Treat Rev 4,3 213-217 9.1977 Krebs setzt fibrinolytische Enzyme frei.. Anti-Fibrinolytische Mittel reduzieren Krebswachstum.. | |
| Heyes, Glück: "Die Bedeutung des Fibrins/Fibrinogens für Wachstum und Metastasierung von Malignomen" Klin Wochenschr 55,22 1079-1087 15.11.1977 Fibrinansammlung bei bösartigen Tumoren.. | |
| Lewis: "Laetrile" West J Med 127 55-62 7.1977 guter Artikel zur Vitamin B17-Problematik.. wer hat nun recht? vgl. Sugiuras anerkannte 200 papers vor Laetrile.. wenn man will daß Experimente scheitern so lässt man sie scheitern.. | |
| "Rutherford v. United States" No. CIV-75-0218-B 438 F Supp 1287 5.12.1977 Fall Rutherford vor Gericht.. Nutzbarkeit Laetrile=Amygdalin bei Menschen unklar weil FDA Tests verhindert hat.. Laetrile war kommerziell verfügbar in den USA 1952-1964.. Latrile-Verbote vor 29.7.1977 unbegründet.. Laetrile kein neues zulassungspflichtiges Medikament.. 690000 neue Krebsfälle 1977.. | |
| Russell: "Biologist says laetrile effective in mice tests; Specialists skeptical" Star, Washington (DC) 10.9.1977 | |
| Manner, DiSanti, Maggio et al: "The remission of spontaneous mammary tumors in mice with amygdalin therapy" Memorandum erteilt am Annual Midwestern Meeting of the National Health Federation, Chicago 10.9.1977 | |
| "Medicine: Victories for Laetrile's Lobby" Time 109,21 107 23.5.1977 Vitamin B17 zur Krebsbehandlung.. Studie Lewis Thomas, Memorial Sloan-Kettering Cancer Center zeigt Tumorkontrolle.. FDA verweigert Zulassung.. erfolgreiche Gerichtsverfahren.. Information durch Committee for Freedom of Choice in Cancer Therapy etc. durch Filme, Schriften, Besuche bei Krebskranken.. | |
| Manner, DiSanti, Michalsen: "The non-toxicity of amygdalin in laboratory mice" J Science Biol 3 347-349 1977.. Vitamin B17.. | |
| Manner, Michalsen, DiSanti: "Enzymatic analysis of normal and malignant tissues" Illinois State Academy of Science 4.1978 | |
| Manner, DiSanti, Michalsen: "The Death of Cancer. The Story of the Research involving Laetrile that dropped a Bombshell on Orthodoxy" Advanced Century Pub, Chicago 1978.. Erfolg bei Brustkrebs mit Vitamin B17, Enzymen, Vitamin C und Vitamin A.. | |
| Maehder: "Enzymtherapie venöser Gefäßerkrankungen" Die Arztpraxis 9,14 1978 | |
| Schmidt, Newton, Sanders, Lewis, Conn: "Laetrile toxicity studies in dogs" JAMA 239,10 943-947 6.3.1978 Laetrile, Vitamin B17.. toxische Effekte bei Hunden bei extremer Menge.. neurologische Schäden.. vgl. dazu Videos zu menschlichen Einnahmeversuchen.. | |
| Takeuchi, Kochi, Sakaguchi, Nakagawa, Mizutani: "Benzaldehyde as a carcinostatic principle in figs" Agr Biol Chem 42,7 1449-1451 1978 Benzaldehyde reduziert stark Tumorgewicht.. Tabelle.. | |
| Ellison, Byar, Newell: "Special report on Laetrile: the NCI Laetrile review. Results of the National Cancer Institute's retrospective Laetrile analysis" N Engl J Med 299,10 549-552 7.9.1978 68 Fälle Laetrile.. davon einige nicht auswertbar.. 6 CR + PR.. stabile Fälle ausgespart.. siehe Krashen 2008.. | |
| Manner, DiSanti, Maggio, Michalsen, Rowe: "Laetrile therapy: a new approach" J Alt Med Assoc 1 14-15,68,72 1978 Vitamin B17.. | |
| Manner, DiSanti, Maggio, Michalsen, Rowe: "Amygdalin, vitamin A and enzyme induced regression of murine mammary adenocarcinomas" J Manipulative Physiol Ther 1,4 246-248 12.1978 Vitamin B17.. | |
| Mitchell: "Kelin's respiratory chain concept and its chemiosmotic consequences" Science 206 1148-1159 1979 | |
| Pitta, Bergen, Littwin: "Spontaneous regression of a choroidal hemangioma following pregnancy" Ann Ophthalmol 11,5 772-774 5.1979 Spontanrückbildung Tumor nach Schwangerschaft.. Embryo erzeugt pankreatische Enzyme die Tumor der Mutter abstoßen.. | |
| Culliton, Waterfall: "Apricot pits and cancer" Br Med J 1,6166 802-803 24.3.1979 Unterdrückung von Vitamin B17.. | |
| Rendelman: "Dr. Edward Howell: A man with an urgent message" Bestways 5.1979 | |
| Krebs: "The extraction, identification and packaging of therapeutically effective amygdalin" 1979 in Salaman: "Nutrition: The Cancer Answer" Statford Publishing, Menlo Park S.293-302 1984 Vitamin B17.. Herstellung Amygdalin.. Iso-Amygdalin = 50% Amygdalin + 50% non-Amygdalin -> kaum wirksam.. | |
| Petersen, Markle: "Politics and science in the laetrile controversy" Social Studies of Science 9 139-166 5.1979 guter Artikel über Vitamin B17.. wertvolle Quellenangaben.. | |
| Martinek, Berezin: "Artificial light-sensitive enzymatic systems as chemical amplifiers of weak light signals" Photochemistry Photobiology 637-650 29.3.1979 | |
| Kochi, Takeuchi, Mizutani, Mochizuki, Matsumoto, Saito: "Antitumor activity of benzaldehyde" Cancer Treat Rep 64,1 21-23 1.1980 Vitamin B17.. Benzaldehyde gg. Tumoren.. | |
| Heikkila, Cabbat: "The prevention of alloxan-induced diabetes by amygdalin" Life Sci 27,8 659-662 25.8.1980 Diabetes durch Alloxan verhindern durch Vitamin B17.. | |
| Moertel, Ames, Kovach, Moyer, Rubin, Tinker: "A pharmacologic and toxicological study of amygdalin" JAMA 245,6 591-594 13.2.1981 Amygdalin i.V. das meiste ausgeschieden.. 0.5g oral 3x/Tag hebt Cyanin auf 2.1ug/mL.. keine toxische Reaktion.. transiente Reaktion bei einem Patienten mit sehr vielen rohen Mandeln.. | |
| Seeger: "Sanum Redox G, ein wichtiger Redoxkatalysator bei Zellatmungsstörungen" Ärztezeitschrift für Naturheilverfahren 22 9 510-515 1981 Cytochrom überträgt Sauerstoff.. Zerstörung Cytochrom führt zu Krebs.. zerstörte Atmungskette reparieren durch Elektronenakzeptoren wie Redoxfarbstoff Thionin, organisches Germanium, Ferrilactat, Rechtsmilchsäure, Betazyane der roten Rübe, Anthozyane, Flavone.. SANUM Redox G=Kombination aus Germanium, Thionin, Ascorbinsäure, Rechtsmilchsäure, Ferrilactat, Lecithin, Galactose, Fructose.. | |
| Hogenauer, Mayer, Drews: "The macrophage activating potential of ubiquinones" Folkers, Yamagami, Littaru: "Biochem and Clinical Aspects of Coenzym Q" Elsevier 3 325-334 1981 | |
| Rudney, Nambudiri, Ranganathan: "The regulation of the synthesis of coenzyme Q in fibroblasts and in heart muscle" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier/North-Holland Press 3 279-290 1981 | |
| Richardson, Drzewoski, Ellis, Folkers, Shizukishi, Takemura, Baker: "Reduction of elevated blood pressure by coenzyme Q10" Biomed and Clin Aspects of CoQ10 3 229-234 1981 | |
| Combs, Faria, Leslie, Bonner: "Effect of coenzyme Q10 on adriamycin induced changes in myocardial calcium" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 3 137-144 1981 ok | |
| Iwamoto, Watanabe, Okamoto, Ohata, Folkers: "Clinical effect of coenzyme Q10 on periodontal disease" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q10" Elsevier, Amsterdam 3 109-119 1981 | |
| Charles, Bono: "A review of the preclinical antitumor activity and toxicology of L-asparaginase derived from E. coli" Cancer Treat Rep 65 Suppl 4 39-46 1981 | |
| Holloway, Peterson, Prigge, Gebhard: "Influence of dietary ascorbic acid upon enzymes of sterol biosynthesis in the guinea pig" Biochem Biophys Res Commun 102,4 1283-1289 30.10.1981 | |
| Bishop: "Krebsgene" Spektrum der Wissenschaft 44-56 5.1982 über Q10.. | |
| Moertel, Fleming, Rubin, Kvols, Sarna, Koch, Currie, Young, Jones, Davignon: "A clinical trial of amygdalin (Laetrile) in the treatment of human cancer" N Engl J Med 306,4 201-206 28.1.1982 Vitamin B17 angeblich nutzlos -> siehe Kommentar Krashen 2008.. | |
| Nieper: "New horizons in non-toxic cancer therapy: Beta-carotin, lithium orotate, anavit, bromelain, benzaldehyde, tomosterone, DHEA and ascorbate" J Intl Acad Prevent Med 5-10 11.1982 | |
| Folkers, Shizukuishi, Takemura, Drzewoski, Richardson, Ellis, Kuzell: "Increase in levels of Ig G in serum of patients treated with coenzym Q10" Res Commun Chem Path Pharm 38,2 335-338 1982 | |
| Judy, Hall, Dugan, Toth, Folkers: "Coenzyme Q10 reduction of Adriamycin toxicity" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 4 231-241 1983 | |
| Rokitansky: "15 Jahre operative Behandlung des Mammakarzinoms mit adjuvanter Enzymtherapie" Erfahrungsheilkunde 3 115-116 1983 | |
| Rokitansky: "Brustkrebs - Hilft nur die Radikaloperation?" Apothekerjournal 10 56-62 1983 | |
| Schwartz: "Judicial deflection of scientific questions: pushing laetrile towards medical closure" 13 New Mexico Law Rev 119 1983 juristische Sichtweise, wichtige Quellenangaben.. | |
| Shaya: "The effects of magnetic and radiofrequency and laser fields on the activity of lysozyme" Universität Salford 1983 | |
| Ionescu: "Study of efficiency of Diapulse therapy on the dynamics of enzymes in burned wound" Bull Clin Rev Burn Injuries 1,2 25-26 4.1984 Enzyme.. | |
| Mohandas, Marshall, Duggin, Horvath, Tiller: "Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer" Cancer Res 44,11 5086-5091 11.1984 Glutathion.. | |
| Kishi, Takahashi, Mayumi, Hama: "Protective effect of coenzyme Q on adriamycin in beating heart cells" Biomed Clin Aspects CoQ 4 181-194 1984 | |
| Sugimoto, Ideta, Imanishi, Ono et al: "Effect of CoQ10 in patients with progressive muscular dystrophy and other neuromuscular diseases" Biomed Clin Aspects CoQ 1 243-250 1984 | |
| Langsjoen, Vadhanavikit, Folkers: "Effective treatment with coenzyme Q10 of patients with myocardial disease classes III and IV" Biomed Clin Aspects CoQ 4 325-332 1984 | |
| Nobuyoshi, Saito, Takahira, Kanazawa et al: "Levels of CoQ10 in biopsies of left ventricular muscle and influence of administration of CoQ10" Biomed Clin Aspects CoQ 4 221-230 1984 | |
| Mortensen, Vadhanavakit, Folkers: "Effectiveness of CoQ10 to treat patients with cardiomyopathy and CoQ10 levels in blood and endomyocardial biopsies" Biomed Clin Aspects CoQ 4 391-402 1984 | |
| Cahn, Borzeix: "The effect of ubichinone 50 over the subacute phase of an experimental stroke in the rat" Biomed Clin Aspects CoQ 4 1984 | |
| Mortensen, Vadhanavikit, Folkers: "Deficiency of coenzyme Q10 in myocardial failure" Drugs Exptl Clin Res X,7 497-502 1984 | |
| Zilliken, Moritz, Müller-Steinwachs, Folkers et al: "Double blind clinical study with Q10 in patients with low cardiac function" Biomed Clin Aspects CoQ 4 425-428 1984 | |
| Ernster: "Ubiquinone: redox-enzyme, hydrogen carrier, antioxidant" Biomed Clin Aspects CoQ 4 3-14 1984 | |
| Yamagami, Shibata, Folkers: "Study of coenzyme Q10 in essential hypertension" Biomed Clin Aspects CoQ 4 231-242 1984 | |
| Van Gaal, de Leeuw, Vadhanavikit, Folkers: "Exploratory study on coenzyme Q10 in obesity" Biomed Clin Aspects CoQ 4 369-374 1984 | |
| Hiasa, Ishida, Maeda, Iwano et al: "Effects of coenzyme Q10 on exercise tolerance in patients with stable angina pectoris" Biomed Clin Aspects CoQ 4 291-302 1984 | |
| Langsjoen, Vadhanavikit, Folkers: "Effective treatment with coenzyme Q10 of patients with chronic myocardial disease" Drugs Exp Clin Res 11,8 577-579 1985 | |
| Kamikawa, Kobayashi, Yamashita, Hayashi, Yamazaki: "Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris" Am J Cardiol 56,4 247-251 1.8.1985 | |
| Oda: "Effect of coenzyme Q10 on stress-induced cardiac dysfunction in paediatric patients with mitral valve prolapse: a study by stress echocardiography" Drugs Exp Clin Res 11,8 557-576 1985 | |
| Mortensen, Vadhanavikit, Baandrup, Folkers: "Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure" Drugs Exp Clin Res 11,8 581-593 1985 | |
| Folkers, Vadhanavikit, Mortensen: "Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10" Proc Natl Acad Sci USA 82,3 901-904 2.1985 | |
| Langsjoen, Vadhanavikit, Folkers: "Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10" Proc Natl Acad Sci USA 82,12 4240-4244 6.1985 | |
| Howell: "Enzyme Nutrition: The Food Enzyme Concept" 1985.. warum ist natürliche Nahrung so wertvoll.. was fehlt bei moderner Ernährung.. was macht anfällig für degenerative Erkrankungen.. Enzymbehandlung seit 1930.. | |
| Hirata, Tanaka: "The role of blood platelet and fibrinogen in experimental metastasis in nude mice following whole body X-irradiation" Neoplasma 32,5 547-552 1985 durch Bestrahlung mehr Fibriogen -> mehr Metastasen.. | |
| Kochi, Isono, Niwayama, Shirakabe: "Antitumor activity of a benzaldehyde derivative" Cancer Treat Rep 69,5 533-537 5.1985 Vitamin B17.. Benzaldehyd.. | |
| Yamagami, Takagi, Akagami, Folkers: "Effect on Q10 on essential hypertension, a double blind controlled study" Biomed Clin Aspects CoQ 5 337-344 1986 | |
| Kamei, Fujita, Kanbe, Sasaki, Oshiba, Otami, Matsui-Yuasa, Morisawa: "The distribution and content of ubiquinone in foods" Int J Vitam Nutr Res 56,1 57-63 1986 | |
| Folkers, Wolaniuk, Simonsen, Lyson et al: "Therapy with coenzyme Q10 for muscular dystrophies and neurogenic atrophies by double blind trial" Biomed Clin Aspects CoQ 5 353-358 1986 | |
| Vanfraechem, Picalausa, Folkers: "Effects of CoQ10 on physical performance and recovery in myocardial failure" Biomed Clin Aspects CoQ 5 371-378 1986 | |
| Judy, Hall, Toth, Folkers: "Double blind-double crossover study of coenzyme Q10 in heart failure" Folkers, Yamamura: "Biomedical and clinical aspects of coenzyme Q" Elsevier, Amsterdam 5 315-323 1986 | |
| Schneeberger, Müller-Steinwachs, Anda, Fuchs, Zilliken, Lyson, Muratsu, Folkers: "A clinical double blind and crossover trial with coenzyme Q10 on patients with cardiac disease" Folkers, Yamamura: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 5 325-333 1986 | |
| Oda: "Q10 therapy on the cardiac dysfunction in patients with mitral valve prolapse: dose vs effect and dose vs serum Q10" Biomed Clin Aspects CoQ 5 269-280 1986 | |
| "The metabolic cancer therapy of Harold W. Manner Ph.D" Cancer J Clinicians 36,3 185-189 1986 Liste Veröffentlichungen von Manner.. | |
| Bishop: "The molecular genetics of cancer" Science 235 305-311 1987 über Q10.. | |
| Astumian, Chock, Tsong, Chen, Westerhoff: "Can free energy be transduced from electric noise?" Proc Natl Acad Sci USA 84,2 434-438 1.1987 freie Energie aus elektrischem Rauschen.. | |
| Chen: "Asymmetry and external noise-induced free energy transduction" Proc Natl Acad Sci USA 84,3 729-733 2.1987 freie Energie aus elektrischem Rauschen.. | |
| Byus, Pieper, Adey: "The effect of low-energy 60 Hz environmental electromagnetic fields upon the growth related enzyme ornithine decarboxylase" Carcinogenesis 8 1385-1389 1987 | |
| Folkers, Langsjoen et al: "Biochemical deficiencies of coenzyme Q10 in HIV-infection and the exploratory treatment" Biochem Biophys Res Comm 153,2 888-896 1988 | |
| Langsjoen, Folkers, Lyson, Muratsu, Lyson, Langsjoen: "Effective and safe therapy with coenzyme Q10 for cardiomyopathy" Klin Wochenschr 66,13 583-590 1.7.1988 | |
| Mitchell: "Respiratory chain systems in theory and practice" Kim et al: "Advances in Membrane Biochemistry and Bioenergetics" Plenum Press, New York 25-52 1988 | |
| Richards: "The enzyme knife - a renewed direction for cancer therapy?" J Royal Soc Med 81 284-285 5.1988 John Beards Trophoblastenthese.. Kelley.. | |
| US-Patent 4885167: Wiederherstellung Herzfunktion durch Q10-Therapie. Folkers, Wolaniuk 16.2.1988 -> 5.12.1989 | |
| Astumian, Chock, Tsong, Westerhoff: "Effects of oscillations and energy-driven fluctuations on the dynamics of enzyme catalysis and free-energy transduction" Phys Rev A 39,12 6416-6435 15.6.1989 | |
| Tsong, Liu, Chauvin, Gaigalas, Astumian: "Electroconformational coupling (ECC): An electric field induced enzyme oscillation for cellular energy and signal transductions" Bioelectrochemistry and Bioenergetics 21,3 319-331 6.1989 | |
| Pihko, Saarinen, Paetau: "Wernicke encephalopathy - a preventable cause of death: Report of 2 children with malignant disease" Pediatric Neurology 5,4 237-242 1989 | |
| Beaufort: "Reduction of radiation side-effects by hydrolytic enzymes" Therapeutikon 4,10 577-580 1990 | |
| Baumhackl, Fördermair: "Enzymtherapie bei Multipler Sklerose" Allgemeinmedizin 19,4 169-172 1990 | |
| Robertson, Astumian: "Michaelis-Menten equation for an enzyme in an oscillating electric field" Biophys J 58,4 969-974 1990 | |
| Zilliken: "Eine klinische Doppelblind-Studie mit CoEnzym Q10 und Vitamin E bei herzkranken Patienten" De Orthomoleculaire Koerier 5,24 4-11 1990 | |
| Mortensen, Vadhanavikit, Muratsu, Folkers: "Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure" Int J Tissue React 12,3 155-162 1990 | |
| Langsjoen, Langsjoen, Folkers: "Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy" Am J Cardiol 65,7 521-523 15.2.1990 | |
| Langsjoen, Langsjoen, Folkers: "A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10" Int J Tissue React 12,3 169-171 1.1.1990 | |
| Langsjoen, Folkers, Lyson, Muratsu, Lyson, Langsjoen: "Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy" Int J Tissue React 12,3 163-168 1990 | |
| Willis, Folkers, Tucker, Ye, Xia, Tamagawa: "Lovastatin decreases coenzyme Q levels in rats" Proc Natl Acad Sci USA 87,22 8928-8930 11.1990 Cholesterinsenker reduziert Q10.. | |
| Folkers, Langsjoen, Willis, Richardson, Xia,Ye, Tamagawa: "Lovastatin decreases coenzyme Q levels in humans" Proc Natl Acad Sci USA 87,22 8931-8934 11.1990 Cholesterinsenker reduziert Q10.. | |
| Desser, Rehberger: "Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes" Oncology 47,6 475-477 1990 Enzyme wie Bromelain, Papain stimulieren TNF.. | |
| Howard: "Enzymes and longevity" 1991 Interview mit Dr. Edward Howell.. | |
| Mitchell: "The vital protonmotive role of coenzyme Q" Folkers, Littarru, Yamagami: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 6 3-10 1991 | |
| Langsjoen, Langsjoen, Folkers, Richardson: "Treatment of patients with human immunodeficiency virus infection with coenzyme Q10" Folkers, Littarru, Yamagami: "Biomedical and Clinical Aspects of Coenzyme Q" 6 409-415 1991 | |
| Schardt, Welzel, Schiess, Toda: "Effect of coenzyme Q10 on ischaemia-induced ST-segment depression: A double blind, placebo-controlled crossover study" Folkers, Yamagami, Littarru: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 6 385-403 1991 | |
| Rossi, Lombardo, Testa, Lippa, Oradei, Littarru, Lucente, Coppola, Manzoli: "Coenzyme Q10 in ischaemic cardiopathy" Folkers, Yamagami, Littarru: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 6 321-326 1991 | |
| Oda: "Dose-effect relationship and critical dose of coenzyme Q10 on load-induced cardiac dysfunction in pediatric patients with mitral valve prolapse" Biomed Clin Aspects CoQ 6 247 1991 | |
| Swedberg, Hoffman-Bang, Rehnqvist, Astrom: "Coenzyme Q10 as an adjunctive in treatment of congestive heart failure" 64th Scientific Sessions American Heart Association, Abstract 774-776 1991 | |
| Ursini, Gambini, Paciaroni, Littarru: "Coenzyme Q10 treatment of heart failure in the elderly: Preliminary results" Folkers, Yamagami, Littarru: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 6 473-480 1991 | |
| Poggessi, Galanti, Comeglio, Toncelli, Vinci: "Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. A medium-term randomized double-blind study versus placebo" Curr Ther Res 49,5 878-886 1.1991 | |
| Nishikawa et al: "Evaluations of long-term therapeutic effectiveness of Coenzym Q10 on a case of Kearns-Sayre-syndrome" Folkers, Yamagani, Littarru: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier Science Publishers 375-382 1991 | |
| Bresolin, Moroni, Angelini, Doriguzzi, Castelli, Licciardello, Carenzi, Banfi, Comi, Scarlato: "Ubidecarenone treatment in 50 patients with mitochondrial myopathies: the first double blind trial" Biomed Clin Aspects of CoQ10 6 397-405 1991 | |
| Wilson, Frishman, Giles, Brackett et al: "Coenzyme Q10 therapy and exercise duration in stable angina" Biomed Clin Aspects of CoQ10 6 339-348 1991 Angina pectoris.. | |
| Battino, Ferri, Gattavecchia, Sassi, Lenaz: "Coenzym Q10 as a possible membrane protecting agent against irradiation damages" in Folkers, Yamagami, Littaru: "Biomed and Clin Aspects of Coenzym Q" Elsevier 6 181-190 1991 | |
| Littarru, Lippa, Oradei, Fiorni, Mazzanti: "Metabolic and diagnostic implications of blood CoQ10 levels" Folkers, Yamagami, Littarru: "Biomedical and Clinical Aspects of Coenzyme Q" Elsevier, Amsterdam 6 167-178 1991 | |
| Rusciani, Oradei, Lippa, Perosino, Romagnoli, Aureli, Littaru: "Coenzyme Q10 levels in human light-exposed and unexposed skin" Folkers, Yamagami, Littaru: "Biomedical and clinical aspects of coenzyme Q" Elsevier 6 125-128 1991 | |
| Meola, Velicogna, Bresolin, Fortunato, Moggio, Scarlato: "Effects of CoQ10 on muscle cells and skin fibroblast from patients with mitochondrial myopathies" Biomed and clin aspects of CoQ10 6 383-396 1991 | |
| Stocker, Bowry, Frei: "Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol" Proc Natl Acad Sci USA 88,5 1645-1650 1991 | |
| Folkers: "Critique of 30 years of research on hematopoietic and immunological activities of coenzyme Q10 potentiality for the rapy of aids and cancer" Med Chem Res 2 48-60 1992 | |
| Mohr, Bowry, Stocker: "Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation" Biochim Biophys Acta 1126,3 247-254 1992 | |
| Sun, Sun, Crane, Morre, Lindgren, Low: "Requirement for coenzyme Q in plasma membrane electron transport" Proc Nat Acad Sci USA 89 11126-11130 1992 | |
| Digiesi, Cantini, Bisi, Guarino, Oradei, Littarru: "Mechanism of action of Coenzyme Q10 in essential hypertension" Curr Ther Res Clin Exp 51 668-672 1992 | |
| Ghirlanda, Oradei, Manto, Lippa, Uccioli, Caputo, Greco, Littarru: "Evidence of plasma CoQ10 -lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study" J Clin Pharmacol 33,3 226-229 3.1993 | |
| Chagovetz, Grissom: "Magnetic field effects in model B12 enzymatic reactions. The photolysis of methylcob(III)alamin" Z Physikal Chemie 182 181-188 1993 | |
| Kontush, Hübner, Finckh, Kohlschütter et al: "Supplementation with ubiquinol-10 protects low density lipoprotein against lipid peroxidation more efficiently than supplementation with alpha-tocopherol" 8th Intl Symp Biomed Clin Aspects of CoQ10 68 1993 | |
| Stocker, Bowry, Suarna, Umeda et al: "The role of ubiquinol-10 in the inhibition of radical-mediated low density lipoprotein oxidation" 8th Intl Symp Biomed Clin Aspects of CoQ10 20 1993 | |
| Oda: "Recovery of systolic time intervals by coenzyme Q10 in patients with load-induced cardiac dysfunction: echocardiographic study" 8th Intl Symp Biomed Clin Aspects of CoQ10 27 1993 | |
| Morisco, Trimarco, Condorelli: "Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study" Clin Investig 71,8 Suppl S134-S136 1993 | |
| Atar, Mortensen, Flachs, Herzog: "Coenzym Q10 protects ischemic myocardium in an open-chest swine model" Clin Investig 71,8 Suppl S103-S111 1993 | |
| Crane, Sun, Sun: "The essential functions of coenzym Q" Clin Investig 71,8 Suppl S55-S59 1993 | |
| Folkers: "Heart failure is a dominant deficiency of coenzyme Q10 and challenges for future clinical research on CoQ10" Clin Investig 71,8 Suppl S51-S54 1993 | |
| Folkers, Nylander, Morita: "Involvement of a deficiency of CoQ10 in cancer therapy and blood levels of CoQ10 in cancer patients in Sweden" Proc Natl Acad Sci 1993 | |
| Folkers, Brown, Hanioka, Williams, Quillin, Jafelice: "Involvement of a deficiency of coenzym Q10 in cancer therapy and blood levels of Co Q10 in cancer patients in America" Proc Nat Acad Sci USA 1993 | |
| Folkers, Brown, Judy, Morita: "Survival of cancer patients on therapy with coenzym Q10" Res Commun Biochem Biophys 192 1 241-245 1993 | |
| Judy, Stogsdill, Folkers: "Myocardial preservation by therapy with coenzyme Q10 during heart surgery" Clin Investig 71,8 Suppl S155-S161 1993 | |
| Fujimoto, Kurihara, Hirata, Takeda: "Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases" Clin Investig 71 162-166 1993 | |
| Langsjoen, Langsjoen, Folkers: "Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment" Clin Investig 71,8 Suppl S140-S144 1993 | |
| Ihse, Andren-Sandberg, Nylander, Folkers: "Research on an deficiency of coenzyme Q10 in cancer patients and initiation of treatment with CoQ10" 8 th Intl Symp Biomed Clin Aspects of CoQ10 48 1993 | |
| Judy, Folkers: "Management of chronic fatigue syndrome patients with CoQ10" 8th Intl Symp Biomed Clin Aspects of CoQ10 55 1993 | |
| Nylander, Nordlund: "Response of periodontitis to therapy with coenzyme Q10" 8th Intl Symp Biomed Clin Aspects of CoQ10 37 1993 | |
| Lampertico, Comis: "Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure" Clin Investig 71,8 Suppl S129-S133 1993 | |
| Matsubara, Yamagami, Kishi, Folkers: "Coenzyme Q10 hypertension, a 10-year survey" 8th Intl Symp Biomed Clin Aspects of CoQ10 42 1993 | |
| Mortensen: "Perspectives on therapy of cardiovascular diseases with CoQ10" Clin Investig 71 S116-S123 1993 | |
| Mortensen: "Review of controlled double-blind trials with coenzyme Q10 (ubiqinone) in chronic heart failure and angina pectoris" 8th Intl Symp Biomed Clin Aspects of CoQ10 45 1993 | |
| Hanioka, Shizukuishi, Folkers: "Effect of topical application of coenzyme Q10 on adult periodontitis" 8th Intl Symp Biomed Clin Aspects of CoQ10 38-39 1993 | |
| McCann: "Pancreatic enzyme supplement for treatment of multiple food allergies" Ann Allerg 71 269 1993 | |
| Fujita, Nomura, Hong, Ito, Asada, Nishimuro: "Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan" Biochem Biophys Res Commun 197,3 1340-1347 30.12.1993 | |
| Ransberger: "Max Wolf - Ein Leben für die Enzymtherapie" Forum-Medizin 1994.. Biografie des Begründers der Enzymtherapie.. | |
| Digiesi, Cantini, Oradei, Bisi, Guarino, Brocchi, Bellandi, Mancini, Littarru: "Coenzyme Q10 in essential hypertension" Mol Aspects Med 15 Suppl s257-s263 1994 Blutdruck.. | |
| Hanioka, Tanaka, Ojima, Shizukuishi: "Effect of topical application of coenzyme Q10 an adult periodontitis" Mol Aspects Med 15 S241-S248 1994 | |
| Chello, Mastroroberto, Romano, Bevaqua, Pantaleo, Ascione, Marchese, Spampinato: "Protecting by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting" Ann Thorac Surg 58,5 1427-1432 1994 | |
| Iarussi, Auricchio, Agretto, Murano, Giuliano, Indolfi, Iacono: "Protective effect of Coenzym Q10 on Anthracyclines cardiotoxicity: Control study in children with acute lymphoblastic Leukemia and non-Hodgkin-Lymphoma" Molec Aspects Med 15 S207-S212 1994 | |
| Valls, Castelluccio, Fato, Genova, Bovina, Saez, Marchetti, Castelli, Lenaz: "Protective effect of exogenous coenzyme Q against damage by Adriamycin in perfused rat liver" Biochem Biomol Biol Int 33,4 633-642 1994 | |
| Langsjoen, Langsjoen, Langsjoen, Willis, Folkers: "Usefulness of coenzyme Q10 in clinical cardiology: a long-term study" Mol Aspects Med 15 S165-S175 1994 | |
| Baggio, Gandini, Plancher, Passeri, Carmosino: "Italian multicenter study on safety and efficacy of coenzyme Q10 adjunctive therapy in heart failure" Mol Aspects Med 15 S287-S294 1994 | |
| Oda: "Recovery of the Frank-Starling mechanism by coenzyme Q10 in patients with load-induced contractility depression" 8th Intl Symp Biomed Clin Aspects of Coenzyme Q Littarru, Battino, Folkers: "The Molecular Aspects of Medicine" 15 S149-S154 1994 | |
| Langsjoen, Langsjoen, Willis, Folkers: "Treatment of essential hypertension with coenzyme Q10" 8th Intl Symp Biomed Clin Aspects of Coenzyme Q Littarru, Battino, Folkers: "The Molecular Aspects of Medicine" 15 S265-S272 1994 | |
| Digiesi, Cantini, Oradei, Bisi et al: "Coenzyme Q10 in essential hypertension" 8th Intl Symp Biomed Clin Aspects of CoQ10 44 1993 Mol Aspects Med 15 S257-S263 1994 | |
| Mancini, de Marinis, Oradei, Littarru, Conte, Pozza, Hallgass: "Coenzyme Q10 concentrations in normal and pathological human seminal fluid" J Androl 15,6 591-594 1994 | |
| Luft: "The development of mitochondrial medicine" Proc Natl Acad Sci 91 8731-8738 1994 | |
| Lodi, Iotti, Scorolli, Bargossi, Sprovieri, Zaniol, Meduri, Barbiroli: "The use of phosphorus magnetic resonance spectroscopy to study in vivo the effect of coenzym Q10 treatment in retinitis pigmentosa" Molec Aspects Med 15,1 S221-S230 1994 | |
| Lockwood, Moesgaard, Hanioka, Folkers: "Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10" Mol Aspects Med 15 S231-S240 1994 | |
| Lockwood, Moesgaard, Folkers: "Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10" Biochem Biophys Res Commun 199,3 1504-1508 30.3.1994 | |
| Mellstedt, Osterborg, Nylander, Morita, Folkers: "A deficiency of coenzyme Q10 (CoQ10) in conventional cancer therapy and blood levels of CoQ10 in cancer patients in Sweden" 8th Intl Symp Biomed Clin Aspects of Coenzyme Q 47 1993 The Molecular Aspects of Medicine 1994 | |
| Folkers, Simonsen: "Two successful double-blind trials with coenzyme Q10 on muscular dystrophies and neurogen. Atrophies" Biochim Biophys Acta 1271,1 281-286 1995 | |
| Hofmann-Bang, Rehnquist, Swedberg, Wiklund, Aström: "Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure" J Card Fail 1,2 101-107 3.1995 Q10 Study Group.. | |
| Daneryd, Aberg, Dallner, Ernster, Schersten, Soussi: "Coenzyms Q9 and Q10 in skeletal and cardiac muscle in tumor-bearing exercising rats" Eur J Cancer 31A 5 760-765 1995 | |
| Lockwood, Moesgaard, Yamamoto, Folkers: "Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases" Biochem Biophys Res Commun 212,1 172-177 6.7.1995 | |
| Kontush, Hübner, Finckh, Kohlschütter, Beisiegel: "Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low density lipoprotein" Biochim Biophys Acta 1258,2 177-187 1995 | |
| Cichoke: "The effect of systemic enzyme therapy on cancer cells and the immune system" Townsend Letter for Doctors and Patients 30-32 11.1995 | |
| Fujita, Hong, Ito, Misawa, Takeuchi, Kariya, Nishimuro: "Transport of nattokinase across the rat intestinal tract" Biol Pharm Bull 18,9 1194-1196 9.1995 | |
| Billigmann: "Enzymtherapie - eine Alternative bei der Behandlung des Zoster. Eine kontrollierte Studie an 192 Patienten" Fortschr Med 113,4 43-48 1995 | |
| Canfield, Belford, Debrunner: "Calculations of earth-strength steady and oscillating magnetic field effects in coenzyme B12 radical pair systems" Mol Phys 89 889-930 1996 | |
| Koroshetz et al: "Assessment of energy metabolism defects in Huntington's disease and possible therapy with coenzym Q10" Ann Neurol 1996 | |
| Horsting, Strijks: "Q10 therapy in patients with Parkinson's disease" 9th Intl Symp Biomed Clin Aspects of CoQ10 9 58 1996 | |
| Nylander: "CoQ10: a therapeutic adjuvant in periodontal disease" 9th Intl Symp Biomed Clin Aspects of Coenzyme Q 9 41-42 1996 | |
| Langsjoen, Langsjoen, Willis, Folkers: "Treatment of hypertrophic cardiomyopathy with coenzyme Q10" Mol Aspects Med 18 S145-S151 1997 | |
| Lewin: "The effect of coenzyme Q10 on sperm motility" 9th Intl Symp Biomed Clin Aspects of Coenzyme Q 9 47 1996 | |
| Chello, Mastroroberto, Romano, Castaldo, Bevaqua, Marchese: "Protecting by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping" J Cardiovasc Surg 37 229-235 1996 | |
| Beal: "Neuroprotective effects of CoQ in models of neurodegenerative diseases" 9th Intl Symp Biomed Clin Aspects of Coenzyme Q 9 30-32 1996 | |
| Oberley, Oberley: "Antioxidant enzyme levels in cancer" Histol Histopathol 12,2 525-535 4.1997 bei Krebs meist wenig antioxidante Enzyme.. | |
| Tiedge, Lortz, Drinkgern, Lenzen: "Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells" Diabetes 46,11 1733-1742 11.1997 wenig antioxidative Enzyme bei Diabetes.. | |
| Koroshetz et al: "Energy metabolism defects in Huntington's disease and effects of Coenzym Q10" Ann Neurol 41 160-165 1997 | |
| Beal: "Coenzyme Q10 as a potential treatment for neurodegenerative diseases" 1st Conf Intl Coenzyme Q10 Association 52-53 1998 | |
| Langsjoen, Langsjoen: "Overview of the use of CoQ10 in cardiovascular disease" Biofactors 9,2-4 273-284 1999 | |
| Mortensen: "Coenzyme Q10 and the diseased heart: blood and tissue levels of CoQ10 in relation to myocardial function and CoQ10 therapy" 1st Conf Intl Coenzyme Q10 Association, Boston 78-80 1998 | |
| Judy, Willis, Folkers: "Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with CoQ10" 1st Conf Intl Coenzyme Q10 Association, Boston 143 1998 600mg/Tag -> Prostata kleiner bei 10 von 14 Pat.. PSA-Wert reduziert.. Lymphozyten-Zahl normalisiert.. nach 360 Behandlungstagen PSA -74%, Prostatagröße -48%.. keine Nebenwirkungen.. | |
| Judy, Stogsdill, Folkers: "Dose related effectiveness of coenzyme Q10 in the treatment of chronic fatigue" 1st Conf Intl Coenzyme Q10 Association, Boston 86 1998 | |
| Nylander, Malmsten: "A double blind dose-response study on effects of coenzyme Q10 on quality of life" 1st Conf Intl Coenzyme Q10 Association, Boston 84 1998 | |
| Gvozdjakova, Kucharsk, Nraunov, Koles: "Beneficial effect of CoQ10 on the antioxidative status and metabolism of fats and sugars in diabetic patients" 1st Conf Intl Coenzyme Q10 Association, Boston 95-97 1998 | |
| Rastogi, Singh, Shukla: "Randomized, double-blind, placebo controlled trial of hydrosoluble coenzyme Q10 in patients with hyperinsulinemia" 1st Conf Intl Coenzyme Q10 Association, Boston 118 1998 | |
| Scaglione, Lundstrom, Barbieri, Lund: "Coenzyme Q10 as an immunoenhancer: A single blind placebo and randomized clinical study" 1st Conf Intl Coenzyme Q10 Association, Boston 89-90 1998 | |
| Shults, Haas, Beal: "A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease" 1st Conf Intl Coenzyme Q10 Association, Boston 54-55 1998 | |
| Singh: "New developments in the cardioprotective effects of coenzyme Q10" 1st Conf Intl Coenzyme Q10 Association, Boston 64 1998 | |
| Syrkin, Kogan, Drynitsina, Kuznetsov, Pechorina, Frenkel: "The effect of soluble form of Coenzyme Q10 on the oxygen free radical processes and clinical course in patients with coronary heart disease - stable angina pectoris" 1st Conf Intl Coenzyme Q10 Association, Boston 110-111 1998 | |
| Wander, Singh, Shukla: "Randomized double blind trial of hydrosoluble Coenzyme Q10 in hypertensives with oxidative stress and coronary artery" 1st Conf Intl Coenzyme Q10 Association, Boston 144 1998 | |
| Syburra: "Oxidative stress in patients with multiple sclerosis" 1st Conf Intl Coenzyme Q10 Association, Boston 125-126 1998 | |
| Weber, Flor, Heidenreich, Zernikow, Menke, Giffei, Hennecke, Andler: "Maternal and neonatal coenzyme Q10 serum levels" 1st Conf Intl Coenzyme Q10 Association, Boston 75-76 1998 | |
| Wald, Olejar, Pouckova, Zadinova: "Proteinases reduce metastatic dissemination and increase survival time in C57B16 mice with the Lewis lung carcinoma" Life Sciences 63,17 237-243 1998 ohne Enzyme 90% der Tiere innerhalb 18 Tagen tot.. Überleben nach 100 Tagen in Gruppe A 60% (Enzyme nach Primärtumorentfernung), Gruppe B 90% (Enzyme schon 6 Tage vorher), Gruppe C 100% (Enzyme 24h nach Tumorimpfung).. | |
| Wald, Olejar, Pouckova, Zadinova: "The influence of proteinases on in vivo blastic transformation in rat species SD/Ipcv with spontaneous lymphoblastic leukemia" Br J Haematology 102,1 294 1998 mit Trypsin, Chymotrypsin, Papain weniger "blast cells" im peripheren Blut.. 150 Tage Überlebenszeit vs. 43 Tage.. 50% überleben 366 Tage vs. keine.. Gewichtszuwachs vs. Gewichtsverlust.. | |
| Sakalova, Dedik, Gazova, Hanisch, Schiess: "Survival analysis of an adjuvant therapy with oral enzymes in multiple myeloma patients" Br J Haematol 102 353-356 1998 | |
| Syrigos, Rowlinson-Busza, Epenetos: "In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody" Int J Cancer 78,6 712-719 9.12.1998 Amygdalin, Vitamin B17.. | |
| Rosenfeldt, Pepe, Ou, Lew, Madani, Rowland, Nagley, Linnane: "Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue" Biofactors 9,2-4 291-299 1999 | |
| Wald, Pouckova, Hlouskova, Altnerova, Olejar: "The influence of trypsin, chymotrypsin and papain on the growth of human pancreatic adenocarcinoma transplanted to nu/nu mice" European J Cancer 35,4 543-548 1999 Mäuse mit menschlichem Bauchspeicheldrüsenkrebs und Trypsin, Chymotrypsin, Papain bewirkt Wachstumsverzögerung vs. Salzwasser.. | |
| Popiela, Kulig, Klek, Wachol, Bock, Hanisch: "Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer" Przegl Lek 57 Suppl 5 142 2000 bessere Lebensqualität, reduzierte Nebenwirkungen.. | |
| Uhder: "Die Beeinflussung von Nebenwirkungen der Strahlentherapie des Beckens durch hydrolytische Enzyme. Eine randomisierte Doppelblindstudie" Dissertation Heinrich-Heine Universität Düsseldorf 2000 scheinbar kein Nutzen durch Enzyme.. | |
| Mortensen: "Coenzyme Q10 as an adjunctive therapy in patients with congestive heart failure" J Am Coll Cardiol 36,1 304-305 7.2000 | |
| Sumi, Sasaki, Yatagai, Kozaki: "Determination and properties of the fibrinolysis accelerating substance (FAS) in Japanese fermented soybean Natto" Nippon Nogeikagaku Kaishi 74,11 1259-1264 11.2000 japanisch.. Grafik der Aktivität unterschiedlicher Blutverdünner.. | |
| Kousparou, Epenetos, Deonarain: "Antibody-guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells" Int J Cancer 99,1 138-148 1.5.2002 Enzyme gg. Krebs.. Tumorkontrolle durch Cyanide.. Linamarin, Vitamin B17.. | |
| Yang, Lam, Hammad, Oberley, Oberley: "Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium" J Oral Pathol Med 31,2 71-77 2.2002 wenig antioxidative Enzyme bei Krebs.. | |
| Kwon, Hong, Hahn, Kim: "Apoptosis induction of Persicae Semen extract in human promyelocytic leukemia (HL-60) cells" Arch Pharm Res 26,2 157-161 2.2003 Amygdalin, Vitamin B17.. | |
| Fukuda, Ito, Mukainaka, Tokuda, Nishino, Yoshida: "Anti-tumor promoting effect of glycosides from Prunus persica seeds" Biol Pharm Bull 26,2 271-273 2.2003 Amygdalin, Vitamin B17.. Grafiken.. | |
| Roberts: "A critique of the Kelley nutritional-metabolic cancer program" Townsend Letter for Doctors & Patients 6.2003 gute Zusammenfassung über Kelley, Beard und Bestätigung durch Krichevsky, Acevedo.. wichtige Quellen zum Nutzen von Enzymen.. | |
| Langsjoen, Langsjoen: "The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10: A review of animal and human publications" Biofactors 18,1-4 101-111 2003 | |
| Wilson: "The rise and fall of Laetrile" 2004 Enzymmischung Mutagen mit Chymotrypsin.. | |
| Damian, Ellenberg, Gildemeister, Lauermann, Simonis, Sauter, Georgi: "Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study" Circulation 110,19 3011-3016 9.11.2004 3-Monatsüberleben nach Wiederbelebung durch Hypothermie (35°C über 24h) + CoQ10 68% vs. Plazebo 29%.. 250mg flüssiges CoQ10.. keine Nebenwirkungen.. S100-Eiweiß 24h nach Herzstillstand signifikant geringer in Gruppe mit CoQ10 (0.47 vs. 3.5ng/mL).. | |
| Garami, Schuler, Babosa, Borgulya, Hauser, Müller, Paksy, Szabó, Hidvégi, Fekete: "Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients" J Pediatr Hematol Oncol 26,10 631-635 10.2004 Weizengrasextrakt reduziert Fieber durch Chemo.. | |
| Lee: "Fluoride - a modern toxic waste" 7.3.2005 Geschichte der Trinkwasserfluoridierung.. toxische Effekte, Alterung, Krebs, Immunsystem unter 4ppm.. 130 Mio Amerikaner vergiftet.. Studien Dr. Dean Burk 1977 -> 10000 Krebstote/Jahr durch Fluor.. 3-6 Monate destilliertes Wasser kann Fluorid reduzieren.. Fluorid reduziert Magnesium, Kalzium.. Fluorid zerstört Enzyme bei 0.1-2ppm (DNA-Reparatur etc.).. Krebs durch Fluorid bei Ratten: Mund, Knochenkrebs, Schilddrüse, Leberkrebs (Hepatocholangiocarcinoma).. keine besseren Zähne durch Fluor.. | |
| Park, Yoon, Han, Zheng, Jung, Uhm, Lee, Jeong, Joo, Yim, Chung, Hong: "Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells" World J Gastroenterol 11,33 5156-5161 7.9.2005 Amygdalin, Vitamin B17.. Grafiken.. | |
| Illmer, Madlener, Horvath, Saiko, Losert, Herbacek, Grusch, Krupitza, Fritzer-Szekeres, Szekeres: "Immunologic and biochemical effects of the fermented wheat germ extract Avemar" Exp Biol Med (Maywood) 230,2 144-149 2.2005 fermentierter Weizenkeimextrakt mit Antitumoreffekt bei Darmkrebs.. Vitamin C verstärkt Nutzeffekt.. | |
| Belardinelli, Muçaj, Lacalaprice, Solenghi, Principi, Tiano, Littarru: "Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure" Biofactors 25,1-4 137-145 2005 | |
| Winterle, Einarsdottir: "Photoreactions of cytochrome C oxidase" Photochem Photobiol 82,3 711-719 2006 Photoreduktion von cytochrome C oxidase durch Laser 266, 355, 532nm.. Eisen.. Metalloenzyme.. | |
| Lim, Macleod, Carr, Manas, Quinton, James: "Carcinoid tumour: spontaneous regression following pregnancy" Endocrine Abstracts 11 P140 2006 Spontanrückbildung Tumor nach Schwangerschaft.. Embryo erzeugt pankreatische Enzyme die Tumor der Mutter abstoßen.. | |
| Chang, Shin, Yang, Lee, Kim, Lee, Kim, Kim, Kim: "Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells" BiolPharm Bull 29,8 1597-1602 8.2006 Vitamin B17 bei Krebs wirksam.. Grafiken.. | |
| Milazzo, Ernst, Lejeune, Schmidt: "Laetrile treatment for cancer" Cochrane Database Syst Rev 2 CD005476 19.4.2006 bessere Auswertung.. vgl. Krashen.. | |
| Milazzo, Lejeune, Ernst: "Laetrile for cancer: a systematic review of the clinical evidence" Support Care Cancer 15,6 583-595 6.2007 bessere Auswertung.. vgl. Krashen.. | |
| Aminlari, Malekhusseini, Akrami, Ebrahimnejad: "Cyanide-metabolizing enzyme rhodanese in human tissues: comparison with domestic animals" Comp Clin Pathol 16,1 47-51 3.2007 Cyanid-Abbau.. | |
| Marcoff, Thompson: "The role of coenzyme Q10 in statin-associated myopathy: a systematic review" J Am Coll Cardiol 49,23 2231-2237 12.6.2007 Cholesterinsenker -> Q10-Mangel -> Herzprobleme.. | |
| Rosenfeldt, Haas, Krum, Hadj, Ng, Leong, Watts: "Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials" J Hum Hypertens 21,4 297-306 4.2007 Blutdrucksenkung durch Q10 Systole/Diastole 167.7/103 -> 151.1/94.8mm Hg (-16.6/-8.2) randomisiert.. -11/-8mm Hg Crossover-Studie.. 162/148.6 -> 97.1/86.8mm Hg (-13.5/10.3) Open Label Studien.. durch Q10 Potential 17/10mm Hg ohne signifikante Nebenwirkungen.. | |
| Báez, Lopes, Salas, Hernández: "In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain" Planta Med 73,13 1377-1383 10.2007 gesteigerte Überlebensdauer durch Bromelain.. | |
| Pazur, Schimek, Galland: "Magnetoreception in microorganisms and fungi" Central European J Biology 2,4 597-659 12.2007 magnetische Effekte (statisch/Wechselfelder) auf Bakterien, Pilze und Enzyme.. | |
| Krashen: "Inaccurate reporting of the effects of laetrile: mistreatment of Ellison, Byar and Newell (1978) in professional papers" Internet J Alternative Med 6,2 2008 Tabelle über unterschiedliche Behandlungserfolge mit Vitamin B17.. 18/22 positiv oder nur 6/68 positiv.. Laetrile voreilig verbannt.. von 68 Fällen nur 22 auswertbar.. 6 Fälle positiv und 9 Fälle stabil -> 15 Fälle von 22 günstig statt wie angegeben nur 6 von 68.. | |
| Krashen: "Does laetrile work? Another look at the Mayo clinic study (Moertel et al., 1982)" Internet J Alternative Med 7,1 2008 warum die Studie von Moertel zu Vitamin B17 unseriös war.. nur 15% Amygdalinanteil im Testmaterial.. ungünstige Mischung.. | |
| Moss: "Enzymes, trophoblasts, and cancer: the afterlife of an idea (1924-2008)" Integr Cancer Ther 7,4 262-275 12.2008 John Beards Enzymtherapie 1905-1911.. Marshall William McDuffie, Frank LeForest Morse, Franklin Lloyd Shively, William Donald Kelley.. pankreatische Enzyme.. | |
| Jonathan Wright: "Nattokinase: An effective answer to hypercoagulation" 2008 | |
| Milner: "Nattokinase: A potent and safe thrombolytic" 2008 auf natürliche Weise Blutverklumpung vermeiden.. Nattokinase wirksamer als Knoblauch, Bromelain, Ginseng.. gg. Arteriosklerose, Thrombosen im Auge etc, koronare Herzkrankheit, Lungenembolie, Diabetes, hohen Blutdruck, periphere Verschlußkrankheit, Schlaganfall, Migräne, Fibromyalgie, CFS, Lyme, Krämpfe, Knochenschmerzen.. | |
| Molyneux, Florkowski, George, Pilbrow, Frampton, Lever, Richards: "Coenzyme Q10: an independent predictor of mortality in chronic heart failure" J Am Coll Cardiol 52,18 1435-1441 28.10.2008 bei Herzversagen wenig Q10 als Kofaktor für Elektronentransport in Mitochondrien und Herzenergie.. höhere Sterblichkeit bei wenig Cholesterin.. Zusammenhang Q10 mit LDL-Cholesterin.. 236 Patienten mit Herzversagen, 77 Jahre.. Q10 gibt Hinweis auf Überleben.. | |
| Heidenreich: "Relevanz proteolytischer Enzyme in der Komplementäronkologie" Masterthese Donau-Universität Krems 2009 Studien zum Nutzen von Enzymen.. | |
| Kumar, Kaur, Devi, Mohan: "Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome" Pharmacol Ther 124,3 259-268 12.2009 | |
| Gonzalez, Isaacs: "The evolution of enzyme treatment adopted from the Trophoblast and the origins of cancer" The Original Internist 3 28-33,41 3.2010 Geschichte der Enzymbehandlung.. sehr wertvoller Text zu Hintergründen.. Tests pankreatischer Enzyme.. | |
| Fischer, Holliday, Thornton: "The CoFactor database: organic cofactors in enzyme catalysis" Bioinformatics 26,19 2496-2497 2010 | |
| Han, Gziri, Van Calsteren, Amant: "Cervical cancer in pregnant women: treat, wait or interrupt? Assessment of current clinical guidelines, innovations and controversies" Ther Adv Med Oncol 5,4 211-219 7.2013 Spontanrückbildung Cervicalkrebs bei 48-70% während Schwangerschaft.. Embryo erzeugt pankreatische Enzyme die Tumor der Mutter abstoßen.. | |
| Fotino, Thompson-Paul, Bazzano: "Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis" Am J Clin Nutr 97,2 268-275 2.2013 | |
| Alehagen, Johansson, Björnstedt, Rosén, Dahlström: "Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens" Int J Cardiol 167,5 1860-1866 1.9.2013 | |
| Skarlovnik, Janic, Lunder, Turk, Sabovic: "Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study" Med Sci Monit 20 2183-2188 6.11.2014 | |
| Mortensen, Rosenfeldt, Kumar, Dolliner, Filipiak, Pella, Alehagen, Steurer, Littarru: "The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial" JACC Heart Fail 2,6 641-649 12.2014 CoQ10 wichtig für Energieerzeugung, Antioxidanz.. Zusammenhang wenig Q10 am Herz mit Herzversagen.. 2 Jahres-Studie 400 Patienten 100mg Q10 3x/Tag vs. Plazebo.. Herzkreislaufsterblichkeit 9% vs. 16%, Sterblichkeit 10% vs. 18%, weniger Krankenhausaufenthalt.. | |
| Aminlari, Tavana, Kazemipour: "Rhodanese distribution in different tissues of rabbits" Comp Clin Pathol 23,5 1259-1262 9.2014 Rhodanese entgiftet Cyanid.. am meisten in Leber, Nieren, Herz, Magen.. | |
| Sewpaul, Bargiela, James, Johnson, French: "Spontaneous regression of a carcinoid tumor following pregnancy" Case Reports in Endocrinology 481823 2014 Frau, 35 verliert Tumor durch Schwangerschaft.. Embryo erzeugt pankreatische Enzyme die Tumor der Mutter abstoßen.. | |
| Sanoobar, Dehghan, Khalili, Azimi, Seifar: "Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial" Nutr Neurosci 19,3 138-143 2016 CoQ10 500mg/Tag vs. Plazebo über 12Wo bessert Müdigkeit.. | |
| Ki, Kim, Kim, Kim, Bae, Park, Jeon, Lee, Lee, Nam: "Effect of coenzyme Q10 on radiation nephropathy in rats" J Korean Med Sci 32,5 757-763 5.2017 | |
| Lei, Li: "Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials" BMC Cardiovasc Disord 17 196 2017 | |
| Alehagen, Aaseth, Alexander, Johansson: "Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly" PLoS One 13,4 e0193120 11.4.2018 | |
| De Barcelos, Haas: "CoQ10 and aging" Biology (Basel) 8,2 28 6.2019 bei Alterung Funktion Mitochondrien beeinträchtigt, weniger Antioxidation, mehr oxidativer Stress/ROS.. Q10-Spiegel sinkt.. 1955 Entdeckung Q10.. Q10 als Antioxidanz, Reduktion Vitamin E/Vitamin C, Mitochondrien Elektronentransport.. Q10 vom menschlichen Körper hergestellt.. Q10 in Schwein, Lamm, Rind, Huhn, Herz, Hühnerbein, Fisch, Hering, Forelle, Spinat, Erbsen, Broccoli, Blumenkohl, Orangen, Erdbeeren, Apfel, Roggen, Weizen.. Tiermodelle.. Q10 ggf. nützlich bei Endothel-Dysfunktion, Entzündung, Osteoporose, Krebs.. | |
| Lopez-Lluch, Lluch: "The important role of CoQ10 in aging" Antioxidants (Basel) 8,12 570 12.2019 Q10 als essentieller Fettstoff in allen Zellmembranen.. Elektronentransferfaktor in Mitochondrien.. Antioxidanz.. bei Mangel Dysfunktion Mitochondrien, Alterung, Alterserkrankungen, Herzkreislauferkrankung, Diabetes, Stoffwechselerkrankungen, neurodegenerative Erkrankungen.. Q10 zur Prävention Herzkreislauferkrankungen, zur Reparatur Schäden nach Herzinfarkt, zur Prävention von Arteriosklerose, Alzheimer, Parkinson.. | |
| Castro-Marrero, Segundo, Lacasa, Martinez-Martinez, Sentañes, Alegre-Martin: "Effect of dietary coenzyme Q10 plus NADH supplementation on fatigue perception and health-related quality of life in individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A prospective, randomized, double-blind, placebo-controlled trial" Nutrients 13,8 2658 8.2021 ME/CFS komplexe Multisystem-Neuroimmunerkrankung, ggf. nach viraler Erkrankung.. keine genaue Diagnose/Labortests.. keine wirksamen Medikamente.. 200mg Coenzym Q10, 20mg NADH über 12Wo bessert.. | |
| Claxton, Simmonds, Beresford, Cubbon, Dayer, Gottlieb, Hartshorne-Evans, Kilroy, Llewellyn, Rothery, Sharif, Tierney, Witte, Wright, Stewart: "Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation" Health Technol Assess 26,4 1-128 1.2022 hohe Kosten durch chronisches Herzversagen.. wenig Q10 begünstigend.. Metaanalyse über 7 Studien mit 1371 Teilnehmern zeigt 32% weniger Sterblichkeit durch Q10.. kein Anstieg Nebenwirkungen.. Q10 kosteneffektiver als Standardprotokoll.. | |
| de la Bella-Garzon, Fernandez-Portero, Alarcon, Amian, Lopez-Lluch: "Levels of plasma coenzyme Q10 are associated with physical capacity and cardiovascular risk in the elderly" Antioxidants (Basel) 11,2 279 2.2022 Q10 wichtig für Mitochonien, antioxidativer Schutz Zellen/Gewebe/Blutfette.. bei Mangel Alterung.. weniger Herzkreislaufrisiko (Cholesterin/HDL-Cholesterin) bei mehr Q10-Spiegel.. mehr Q10 bei mehr Cholesterin (Grafiken).. Q10 schützt vor Oxidation LDL-Lipoprotein.. bei weniger Q10 Organversagen -> Q10-Spiegel aufrechterhalten.. weniger Q10 bei Übergewicht.. Messung bioelektrische Impedanz (Tanita BF 350) für Bestimmung Körperfett, Muskelmasse, Fettanteil %, Grundkalorien, metabolisches Alter.. Messung Blutdruck mit OMROM-Monitor.. Fitness-Test -> bei höherer Aktivität mehr Q10.. Q10 im Endothelgewebe Arterien.. Q10 bessert Endothelfunktion.. mehr Aktivität -> mehr Q10, mehr Endothelschutz, weniger Oxidationschaden, weniger Herzkreislauferkrankungen, weniger Arteriosklerose, weniger Muskelfehlfunktion.. Gabe Q10 + Muskelaktivität für bessere Endothelfunktion und weniger Entzündung.. | |
| Barnish, Sheikh, Scholey: "Nutrient therapy for the improvement of fatigue symptoms" Nutrients 15,9 2154 30.4.2023 50 Studien zeigen Nutzen Vitamine/Mineralien auf Müdigkeit.. Coenzyme Q10, L-Carnitine, Zink, Methionine, Nicotinamide adenine dinucleotide (NAD), Vitamin C, Vitamin D, Vitamin B.. | |
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